(19 nodes) (2013) Blockade of bovine PD-1 increases T cell function and inhibits bovine leukemia virus expression in B cells in vitro. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_022257	Actin. (98 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Il10	Interleukin-10. (178 aa)
	CgPICR_002764	Glyceraldehyde-3-phosphate dehydrogenase. (77 aa)
	CgPICR_020194	Glyceraldehyde-3-phosphate dehydrogenase. (105 aa)
	CgPICR_000710	Glyceraldehyde-3-phosphate dehydrogenase. (129 aa)
	CgPICR_000709	Glyceraldehyde-3-phosphate dehydrogenase. (148 aa)
	CgPICR_013910	Glyceraldehyde-3-phosphate dehydrogenase. (104 aa)
	Foxp3	Forkhead box protein P3. (428 aa)
	CgPICR_017739	Glyceraldehyde-3-phosphate dehydrogenase. (163 aa)
	CgPICR_002995	Glyceraldehyde-3-phosphate dehydrogenase. (206 aa)
	CgPICR_017546	Glyceraldehyde-3-phosphate dehydrogenase. (127 aa)
	Cd80	T-lymphocyte activation antigen CD80. (177 aa)
	Ccr7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	Alb	Serum albumin. (430 aa)
	CgPICR_012401	Glyceraldehyde-3-phosphate dehydrogenase. (75 aa)
	CgPICR_008588	Glyceraldehyde-3-phosphate dehydrogenase. (161 aa)
	I79_025220	Serum albumin. (186 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alb	Cd4	G3IAL6	G3GUN9	Serum albumin.	T-cell surface glycoprotein CD4.	0.860
Alb	Cd80	G3IAL6	G3I1J7	Serum albumin.	T-lymphocyte activation antigen CD80.	0.408
Alb	CgPICR_000709	G3IAL6	G3HKA4	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_000710	G3IAL6	G3HKA3	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_002764	G3IAL6	G3HJV9	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_002995	G3IAL6	G3HZA8	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.695
Alb	CgPICR_008588	G3IAL6	G3IHS0	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_012401	G3IAL6	G3ID55	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_013910	G3IAL6	G3HN28	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_017546	G3IAL6	G3I044	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_017739	G3IAL6	G3HYZ4	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_020194	G3IAL6	G3HK68	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.695
Alb	Foxp3	G3IAL6	G3HNB1	Serum albumin.	Forkhead box protein P3.	0.426
Alb	I79_022257	G3IAL6	G3IEV3	Serum albumin.	Actin.	0.738
Alb	I79_025220	G3IAL6	G3IMS5	Serum albumin.	Serum albumin.	0.960
Alb	Ifng	G3IAL6	G3GY20	Serum albumin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.749
Alb	Il10	G3IAL6	G3HB01	Serum albumin.	Interleukin-10.	0.655
Ccr7	Cd4	G3I5N8	G3GUN9	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-cell surface glycoprotein CD4.	0.922
Ccr7	Cd80	G3I5N8	G3I1J7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-lymphocyte activation antigen CD80.	0.752
Ccr7	Foxp3	G3I5N8	G3HNB1	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Forkhead box protein P3.	0.666