(20 nodes) (2014) Identifying vaccine targets for anti-leishmanial vaccine development. network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Lyrm9	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
	Nos1	Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Ctsb	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	I79_004996	Triosephosphate isomerase. (83 aa)
	Cd40	Tumor necrosis factor receptor superfamily member 5. (118 aa)
	Cd86	T-lymphocyte activation antigen CD86. (269 aa)
	Il10	Interleukin-10. (178 aa)
	Eef1b2	Elongation factor 1-beta; Belongs to the EF-1-beta/EF-1-delta family. (225 aa)
	CgPICR_005523	Triosephosphate isomerase. (136 aa)
	Rack1	Guanine nucleotide-binding protein subunit beta-2-like 1. (276 aa)
	I79_012448	Triosephosphate isomerase. (150 aa)
	I79_015041	Thymidylate synthase. (192 aa)
	I79_017439	Triosephosphate isomerase. (187 aa)
	CgPICR_012539	Small ubiquitin-related modifier. (112 aa)
	Tyms	Thymidylate synthase-like protein. (307 aa)
	CgPICR_012325	Small ubiquitin-related modifier. (95 aa)
	I79_025440	Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd4	Cd40	G3GUN9	G3H8U5	T-cell surface glycoprotein CD4.	Tumor necrosis factor receptor superfamily member 5.	0.949
Cd4	Cd86	G3GUN9	G3HAJ6	T-cell surface glycoprotein CD4.	T-lymphocyte activation antigen CD86.	0.955
Cd4	Ctsb	G3GUN9	G3H0L9	T-cell surface glycoprotein CD4.	Cathepsin B; Belongs to the peptidase C1 family.	0.695
Cd4	I79_025440	G3GUN9	G3INC5	T-cell surface glycoprotein CD4.	Cathepsin L1; Belongs to the peptidase C1 family.	0.560
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Lyrm9	G3GUN9	G3GTQ5	T-cell surface glycoprotein CD4.	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family.	0.588
Cd40	Cd4	G3H8U5	G3GUN9	Tumor necrosis factor receptor superfamily member 5.	T-cell surface glycoprotein CD4.	0.949
Cd40	Cd86	G3H8U5	G3HAJ6	Tumor necrosis factor receptor superfamily member 5.	T-lymphocyte activation antigen CD86.	0.968
Cd40	Ifng	G3H8U5	G3GY20	Tumor necrosis factor receptor superfamily member 5.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.902
Cd40	Il10	G3H8U5	G3HB01	Tumor necrosis factor receptor superfamily member 5.	Interleukin-10.	0.858
Cd86	Cd4	G3HAJ6	G3GUN9	T-lymphocyte activation antigen CD86.	T-cell surface glycoprotein CD4.	0.955
Cd86	Cd40	G3HAJ6	G3H8U5	T-lymphocyte activation antigen CD86.	Tumor necrosis factor receptor superfamily member 5.	0.968
Cd86	Ifng	G3HAJ6	G3GY20	T-lymphocyte activation antigen CD86.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.878
Cd86	Il10	G3HAJ6	G3HB01	T-lymphocyte activation antigen CD86.	Interleukin-10.	0.896
CgPICR_005523	I79_012448	G3HIL0	G3HNV4	Triosephosphate isomerase.	Triosephosphate isomerase.	0.558
CgPICR_005523	I79_015041	G3HIL0	G3HVQ1	Triosephosphate isomerase.	Thymidylate synthase.	0.488
CgPICR_005523	Tyms	G3HIL0	G3IFY1	Triosephosphate isomerase.	Thymidylate synthase-like protein.	0.562
CgPICR_012325	CgPICR_012539	G3IH36	G3I572	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.908
CgPICR_012539	CgPICR_012325	G3I572	G3IH36	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.908