(17 nodes) (2015) Exosomes: Implications in HIV-1 Pathogenesis. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Apob	Apolipoprotein B-100. (3537 aa)
	Cxcr4	C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (290 aa)
	Siglec1	Sialoadhesin. (1708 aa)
	Rab5a	Ras-related protein Rab-5A. (215 aa)
	Cd63	Tetraspanin. (232 aa)
	Cdk9	Cell division protein kinase 9; Belongs to the protein kinase superfamily. (372 aa)
	Rab2b	Ras-related protein Rab-2B. (216 aa)
	Cd81	Tetraspanin. (236 aa)
	Rab9a	Ras-related protein Rab-9A. (201 aa)
	Apobec3b	Putative DNA dC->dU-editing enzyme APOBEC3. (413 aa)
	Rab27b	Ras-related protein Rab-27B. (105 aa)
	Cd53	Tetraspanin. (219 aa)
	Rab27a	Ras-related protein Rab-27A. (221 aa)
	Cd9	Tetraspanin. (159 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Cd82	Tetraspanin. (249 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Apob	Cd4	G3GZQ0	G3GUN9	Apolipoprotein B-100.	T-cell surface glycoprotein CD4.	0.493
Apob	Cd81	G3GZQ0	G3HXZ3	Apolipoprotein B-100.	Tetraspanin.	0.469
Apobec3b	Cd4	G3I2J2	G3GUN9	Putative DNA dC->dU-editing enzyme APOBEC3.	T-cell surface glycoprotein CD4.	0.659
Apobec3b	Cd53	G3I2J2	G3IBU5	Putative DNA dC->dU-editing enzyme APOBEC3.	Tetraspanin.	0.459
Apobec3b	Rab2b	G3I2J2	G3HWS3	Putative DNA dC->dU-editing enzyme APOBEC3.	Ras-related protein Rab-2B.	0.510
Apobec3b	Rab9a	G3I2J2	G3I185	Putative DNA dC->dU-editing enzyme APOBEC3.	Ras-related protein Rab-9A.	0.405
Cd4	Apob	G3GUN9	G3GZQ0	T-cell surface glycoprotein CD4.	Apolipoprotein B-100.	0.493
Cd4	Apobec3b	G3GUN9	G3I2J2	T-cell surface glycoprotein CD4.	Putative DNA dC->dU-editing enzyme APOBEC3.	0.659
Cd4	Cd63	G3GUN9	G3HRL6	T-cell surface glycoprotein CD4.	Tetraspanin.	0.736
Cd4	Cd81	G3GUN9	G3HXZ3	T-cell surface glycoprotein CD4.	Tetraspanin.	0.813
Cd4	Cd82	G3GUN9	G3GYG8	T-cell surface glycoprotein CD4.	Tetraspanin.	0.725
Cd4	Cd9	G3GUN9	G3GUL4	T-cell surface glycoprotein CD4.	Tetraspanin.	0.810
Cd4	Cdk9	G3GUN9	G3HV08	T-cell surface glycoprotein CD4.	Cell division protein kinase 9; Belongs to the protein kinase superfamily.	0.564
Cd4	Cxcr4	G3GUN9	G3GZR2	T-cell surface glycoprotein CD4.	C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family.	0.891
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Siglec1	G3GUN9	G3H429	T-cell surface glycoprotein CD4.	Sialoadhesin.	0.739
Cd53	Apobec3b	G3IBU5	G3I2J2	Tetraspanin.	Putative DNA dC->dU-editing enzyme APOBEC3.	0.459
Cd53	Cd82	G3IBU5	G3GYG8	Tetraspanin.	Tetraspanin.	0.546
Cd63	Cd4	G3HRL6	G3GUN9	Tetraspanin.	T-cell surface glycoprotein CD4.	0.736
Cd63	Cd81	G3HRL6	G3HXZ3	Tetraspanin.	Tetraspanin.	0.858