(22 nodes) (2015) Xanthorrhizol: a review of its pharmacological activities and anticancer properties. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_017669	Apoptotic protease-activating factor 1. (434 aa)
	I79_017529	Apoptotic protease-activating factor 1. (444 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	Sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
	Cdk1	Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
	Ccna1	Cyclin-A1; Belongs to the cyclin family. (351 aa)
	Tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Gsk3b	Glycogen synthase kinase-3 beta. (328 aa)
	Mmp9	Matrix metalloproteinase-9. (710 aa)
	Ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Lyrm9	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
	Esr1	Estrogen receptor. (200 aa)
	Nos1	Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
	I79_001487	Progesterone receptor. (741 aa)
	I79_001600	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
	I79_004417	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	I79_021949	Caspase-3; Belongs to the peptidase C14A family. (195 aa)
	I79_020089	Caspase-9; Belongs to the peptidase C14A family. (689 aa)
	I79_018057	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcl2	Ccna1	G3HD46	G3HGB6	Apoptosis regulator Bcl-2.	Cyclin-A1; Belongs to the cyclin family.	0.496
Bcl2	Ccnd1	G3HD46	A5A422	Apoptosis regulator Bcl-2.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.770
Bcl2	Esr1	G3HD46	G3GU19	Apoptosis regulator Bcl-2.	Estrogen receptor.	0.493
Bcl2	I79_001600	G3HD46	G3GV69	Apoptosis regulator Bcl-2.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.993
Bcl2	I79_004417	G3HD46	G3H2K2	Apoptosis regulator Bcl-2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
Bcl2	I79_017529	G3HD46	G3I2A0	Apoptosis regulator Bcl-2.	Apoptotic protease-activating factor 1.	0.768
Bcl2	I79_017669	G3HD46	G3I2M9	Apoptosis regulator Bcl-2.	Apoptotic protease-activating factor 1.	0.768
Bcl2	I79_018057	G3HD46	G3I3P7	Apoptosis regulator Bcl-2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
Bcl2	I79_020089	G3HD46	G3I954	Apoptosis regulator Bcl-2.	Caspase-9; Belongs to the peptidase C14A family.	0.970
Bcl2	I79_021949	G3HD46	G3IE08	Apoptosis regulator Bcl-2.	Caspase-3; Belongs to the peptidase C14A family.	0.938
Bcl2	Ins	G3HD46	G3HXZ8	Apoptosis regulator Bcl-2.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.503
Bcl2	Mmp9	G3HD46	G3H8V1	Apoptosis regulator Bcl-2.	Matrix metalloproteinase-9.	0.608
Ccna1	Bcl2	G3HGB6	G3HD46	Cyclin-A1; Belongs to the cyclin family.	Apoptosis regulator Bcl-2.	0.496
Ccna1	Ccnd1	G3HGB6	A5A422	Cyclin-A1; Belongs to the cyclin family.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.541
Ccna1	Cdk1	G3HGB6	G3HVL1	Cyclin-A1; Belongs to the cyclin family.	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.998
Ccna1	I79_001600	G3HGB6	G3GV69	Cyclin-A1; Belongs to the cyclin family.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.536
Ccna1	I79_004417	G3HGB6	G3H2K2	Cyclin-A1; Belongs to the cyclin family.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.536
Ccna1	I79_018057	G3HGB6	G3I3P7	Cyclin-A1; Belongs to the cyclin family.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.536
Ccna1	I79_020089	G3HGB6	G3I954	Cyclin-A1; Belongs to the cyclin family.	Caspase-9; Belongs to the peptidase C14A family.	0.513
Ccna1	I79_021949	G3HGB6	G3IE08	Cyclin-A1; Belongs to the cyclin family.	Caspase-3; Belongs to the peptidase C14A family.	0.617