(7 nodes) (2015) Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Lpl	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (450 aa)
	I79_015109	Interleukin-6. (174 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	CgPICR_017379	Toll-like receptor 11. (916 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Tlr6	Toll-like receptor. (795 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CgPICR_017379	I79_015109	G3IFP1	G3HVW6	Toll-like receptor 11.	Interleukin-6.	0.462
CgPICR_017379	Tlr3	G3IFP1	G3IHU2	Toll-like receptor 11.	Toll-like receptor 3.	0.683
CgPICR_017379	Tlr4	G3IFP1	G3I192	Toll-like receptor 11.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.509
CgPICR_017379	Tlr6	G3IFP1	G3INL2	Toll-like receptor 11.	Toll-like receptor.	0.511
CgPICR_017379	Tnf	G3IFP1	G3HZG9	Toll-like receptor 11.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.476
I79_015109	CgPICR_017379	G3HVW6	G3IFP1	Interleukin-6.	Toll-like receptor 11.	0.462
I79_015109	Lpl	G3HVW6	G3H6V7	Interleukin-6.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.426
I79_015109	Tlr3	G3HVW6	G3IHU2	Interleukin-6.	Toll-like receptor 3.	0.658
I79_015109	Tlr4	G3HVW6	G3I192	Interleukin-6.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.830
I79_015109	Tlr6	G3HVW6	G3INL2	Interleukin-6.	Toll-like receptor.	0.515
I79_015109	Tnf	G3HVW6	G3HZG9	Interleukin-6.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.772
Lpl	I79_015109	G3H6V7	G3HVW6	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	Interleukin-6.	0.426
Tlr3	CgPICR_017379	G3IHU2	G3IFP1	Toll-like receptor 3.	Toll-like receptor 11.	0.683
Tlr3	I79_015109	G3IHU2	G3HVW6	Toll-like receptor 3.	Interleukin-6.	0.658
Tlr3	Tlr4	G3IHU2	G3I192	Toll-like receptor 3.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.893
Tlr3	Tlr6	G3IHU2	G3INL2	Toll-like receptor 3.	Toll-like receptor.	0.495
Tlr3	Tnf	G3IHU2	G3HZG9	Toll-like receptor 3.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.658
Tlr4	CgPICR_017379	G3I192	G3IFP1	Toll-like receptor 4; Belongs to the Toll-like receptor family.	Toll-like receptor 11.	0.509
Tlr4	I79_015109	G3I192	G3HVW6	Toll-like receptor 4; Belongs to the Toll-like receptor family.	Interleukin-6.	0.830
Tlr4	Tlr3	G3I192	G3IHU2	Toll-like receptor 4; Belongs to the Toll-like receptor family.	Toll-like receptor 3.	0.893