(7 nodes) (2016) Notch-Mediated Cell Adhesion. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fur	Furin endoprotease; Belongs to the peptidase S8 family. (794 aa)
	POFUT1	GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] (392 aa)
	Ank2	Ankyrin-2. (3299 aa)
	Dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (578 aa)
	Notch2	Neurogenic locus notch-like protein 2. (1521 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ank2	Jag1	G3IF65	G3GSA7	Ankyrin-2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.406
Ank2	fur	G3IF65	Q60426	Ankyrin-2.	Furin endoprotease; Belongs to the peptidase S8 family.	0.412
Dll1	Dll4	G3HNT7	G3ICK3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.942
Dll1	Jag1	G3HNT7	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.577
Dll1	Notch2	G3HNT7	G3HP78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 2.	0.978
Dll1	POFUT1	G3HNT7	P83337	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...]	0.651
Dll4	Dll1	G3ICK3	G3HNT7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.942
Dll4	Jag1	G3ICK3	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.503
Dll4	Notch2	G3ICK3	G3HP78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 2.	0.975
Dll4	POFUT1	G3ICK3	P83337	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...]	0.528
Jag1	Ank2	G3GSA7	G3IF65	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Ankyrin-2.	0.406
Jag1	Dll1	G3GSA7	G3HNT7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.577
Jag1	Dll4	G3GSA7	G3ICK3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.503
Jag1	Notch2	G3GSA7	G3HP78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 2.	0.981
Jag1	POFUT1	G3GSA7	P83337	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...]	0.657
Jag1	fur	G3GSA7	Q60426	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Furin endoprotease; Belongs to the peptidase S8 family.	0.425
Notch2	Dll1	G3HP78	G3HNT7	Neurogenic locus notch-like protein 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.978
Notch2	Dll4	G3HP78	G3ICK3	Neurogenic locus notch-like protein 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.975
Notch2	Jag1	G3HP78	G3GSA7	Neurogenic locus notch-like protein 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.981
Notch2	POFUT1	G3HP78	P83337	Neurogenic locus notch-like protein 2.	GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...]	0.501