(32 nodes) (2016) KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics. network (Cricetulus griseus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Vps4b	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (436 aa)
	Hck	Tyrosine-protein kinase. (503 aa)
	Cdc42	Cell division control protein 42-like. (191 aa)
	I79_010752	Alpha-actinin-4. (327 aa)
	Actn4	Alpha-actinin-4. (234 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
	Epha2	Ephrin type-A receptor 2. (942 aa)
	Ep300	Histone acetyltransferase p300. (2415 aa)
	I79_017574	Caspase-12; Belongs to the peptidase C14A family. (729 aa)
	Lyn	Tyrosine-protein kinase. (289 aa)
	Slc9a1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (821 aa)
	Diaph1	Protein diaphanous-like 1. (211 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	I79_014743	Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1071 aa)
	Crk	Proto-oncogene C-crk. (327 aa)
	Fyn	Proto-oncogene tyrosine-protein kinase Fyn. (232 aa)
	Lck	Proto-oncogene tyrosine-protein kinase LCK. (158 aa)
	Pxn	Paxillin. (388 aa)
	I79_001232	Paxillin; Belongs to the phospholipase A2 family. (642 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Vcl	Vinculin. (1143 aa)
	Hgs	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Rabif	Guanine nucleotide exchange factor MSS4. (128 aa)
	Rhoa	Transforming protein RhoA. (193 aa)
	I79_022257	Actin. (98 aa)
	Cib1	Calcium and integrin-binding protein 1. (191 aa)
	Itgb5	Integrin beta; Belongs to the integrin beta chain family. (771 aa)
	I79_025972	Hepatocyte growth factor-regulated tyrosine kinase substrate. (147 aa)
	Ext1	Exostosin-1. (388 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Actn4	Cib1	G3HJB1	G3IHT6	Alpha-actinin-4.	Calcium and integrin-binding protein 1.	0.483
Actn4	I79_001232	G3HJB1	G3GU78	Alpha-actinin-4.	Paxillin; Belongs to the phospholipase A2 family.	0.497
Actn4	I79_010752	G3HJB1	G3HJB0	Alpha-actinin-4.	Alpha-actinin-4.	0.899
Actn4	I79_022257	G3HJB1	G3IEV3	Alpha-actinin-4.	Actin.	0.556
Actn4	Itgb5	G3HJB1	G3GSN8	Alpha-actinin-4.	Integrin beta; Belongs to the integrin beta chain family.	0.751
Actn4	Pxn	G3HJB1	G3GU77	Alpha-actinin-4.	Paxillin.	0.497
Actn4	Rhoa	G3HJB1	G3H8F9	Alpha-actinin-4.	Transforming protein RhoA.	0.560
Actn4	Vcl	G3HJB1	G3GWQ1	Alpha-actinin-4.	Vinculin.	0.983
Brca1	Ep300	G3HM05	G3I534	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone acetyltransferase p300.	0.833
Brca1	Stat1	G3HM05	G3I9F9	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Signal transducer and activator of transcription.	0.602
Brca1	Stat3	G3HM05	G3HLW9	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Signal transducer and activator of transcription.	0.560
Cd4	Cdc42	G3GUN9	G3HIM4	T-cell surface glycoprotein CD4.	Cell division control protein 42-like.	0.484
Cd4	Fyn	G3GUN9	G3HMR9	T-cell surface glycoprotein CD4.	Proto-oncogene tyrosine-protein kinase Fyn.	0.689
Cd4	Hck	G3GUN9	G3HE98	T-cell surface glycoprotein CD4.	Tyrosine-protein kinase.	0.709
Cd4	I79_017574	G3GUN9	G3I2E4	T-cell surface glycoprotein CD4.	Caspase-12; Belongs to the peptidase C14A family.	0.781
Cd4	I79_022257	G3GUN9	G3IEV3	T-cell surface glycoprotein CD4.	Actin.	0.604
Cd4	Il18	G3GUN9	G3H2H9	T-cell surface glycoprotein CD4.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.886
Cd4	Lck	G3GUN9	G3H943	T-cell surface glycoprotein CD4.	Proto-oncogene tyrosine-protein kinase LCK.	0.987
Cd4	Lyn	G3GUN9	G3I2D1	T-cell surface glycoprotein CD4.	Tyrosine-protein kinase.	0.612
Cd4	Rhoa	G3GUN9	G3H8F9	T-cell surface glycoprotein CD4.	Transforming protein RhoA.	0.522