STRINGSTRING
Stat3 Stat3 Gfap Gfap Gclc Gclc Ccna1 Ccna1 Fos Fos Bcl2 Bcl2 Tnfsf9 Tnfsf9 Mmp9 Mmp9 Igf1 Igf1 I79_004417 I79_004417 Sesn2 Sesn2 Nfe2l2 Nfe2l2 Lep Lep Mdm2 Mdm2 Src Src I79_001600 I79_001600 I79_001487 I79_001487 Esr1 Esr1 CgPICR_016246 CgPICR_016246 Gcnt3 Gcnt3 Casp8 Casp8 Ccnd1 Ccnd1 I79_020089 I79_020089 HSPA5 HSPA5 Mtor Mtor I79_021949 I79_021949 Vcam1 Vcam1 I79_021045 I79_021045 Pdcd4 Pdcd4 I79_018057 I79_018057 Hmox1 Hmox1 Ins Ins Pik3c3 Pik3c3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Stat3Signal transducer and activator of transcription. (770 aa)
GfapGlial fibrillary acidic protein; Belongs to the intermediate filament family. (427 aa)
GclcGlutamate--cysteine ligase catalytic subunit. (584 aa)
Ccna1Cyclin-A1; Belongs to the cyclin family. (351 aa)
FosProto-oncogene protein c-fos. (381 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
Tnfsf9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (307 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Sesn2Sestrin-2. (480 aa)
Nfe2l2Nuclear factor erythroid 2-related factor 2. (588 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (476 aa)
SrcTyrosine-protein kinase. (536 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
I79_001487Progesterone receptor. (741 aa)
Esr1Estrogen receptor. (200 aa)
CgPICR_016246Leukotriene-B(4) omega-hydroxylase 2; Belongs to the cytochrome P450 family. (522 aa)
Gcnt3Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3. (437 aa)
Casp8Caspase-8; Belongs to the peptidase C14A family. (481 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
Vcam1Vascular cell adhesion protein 1. (220 aa)
I79_021045Heme oxygenase 1. (81 aa)
Pdcd4Programmed cell death protein 4. (469 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (822 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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