(10 nodes) (2017) Animal Models of Leptospirosis: Of Mice and Hamsters. network (Cricetulus griseus)

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second shell of interactors

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Your Input:
	Cish	Cytokine-inducible SH2-containing protein. (224 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Nos1	Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Lyrm9	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
	Il4r	Interleukin-4 receptor alpha chain. (835 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Il10	Interleukin-10. (178 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cish	Ifng	G3H8B2	G3GY20	Cytokine-inducible SH2-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.588
Cish	Il10	G3H8B2	G3HB01	Cytokine-inducible SH2-containing protein.	Interleukin-10.	0.403
Cish	Il4r	G3H8B2	G3I4F2	Cytokine-inducible SH2-containing protein.	Interleukin-4 receptor alpha chain.	0.637
Ifng	Cish	G3GY20	G3H8B2	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Cytokine-inducible SH2-containing protein.	0.588
Ifng	Il10	G3GY20	G3HB01	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-10.	0.979
Ifng	Il4r	G3GY20	G3I4F2	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-4 receptor alpha chain.	0.809
Ifng	Lyrm9	G3GY20	G3GTQ5	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family.	0.555
Ifng	Myd88	G3GY20	G3HQV3	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.799
Ifng	Tlr3	G3GY20	G3IHU2	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Toll-like receptor 3.	0.775
Ifng	Tlr4	G3GY20	G3I192	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.893
Il10	Cish	G3HB01	G3H8B2	Interleukin-10.	Cytokine-inducible SH2-containing protein.	0.403
Il10	Ifng	G3HB01	G3GY20	Interleukin-10.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.979
Il10	Il4r	G3HB01	G3I4F2	Interleukin-10.	Interleukin-4 receptor alpha chain.	0.833
Il10	Lyrm9	G3HB01	G3GTQ5	Interleukin-10.	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family.	0.450
Il10	Myd88	G3HB01	G3HQV3	Interleukin-10.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.837
Il10	Tlr3	G3HB01	G3IHU2	Interleukin-10.	Toll-like receptor 3.	0.757
Il10	Tlr4	G3HB01	G3I192	Interleukin-10.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.942
Il4r	Cish	G3I4F2	G3H8B2	Interleukin-4 receptor alpha chain.	Cytokine-inducible SH2-containing protein.	0.637
Il4r	Ifng	G3I4F2	G3GY20	Interleukin-4 receptor alpha chain.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.809
Il4r	Il10	G3I4F2	G3HB01	Interleukin-4 receptor alpha chain.	Interleukin-10.	0.833