node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB1 | Nr1i2 | P21448 | G3HAH7 | ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. | Nuclear receptor subfamily 1 group I member 2. | 0.474 |
Edn1 | IL1B | G3H0G9 | G3I1B0 | Endothelin-1. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.544 |
Edn1 | Tlr4 | G3H0G9 | G3I192 | Endothelin-1. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.402 |
IL1B | Edn1 | G3I1B0 | G3H0G9 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Endothelin-1. | 0.544 |
IL1B | IL2 | G3I1B0 | G3HTL8 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.799 |
IL1B | Ocln | G3I1B0 | G3HRV7 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Occludin. | 0.665 |
IL1B | Tlr3 | G3I1B0 | G3IHU2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Toll-like receptor 3. | 0.674 |
IL1B | Tlr4 | G3I1B0 | G3I192 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.852 |
IL1B | Tlr6 | G3I1B0 | G3INL2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Toll-like receptor. | 0.571 |
IL2 | IL1B | G3HTL8 | G3I1B0 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.799 |
IL2 | Tlr3 | G3HTL8 | G3IHU2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Toll-like receptor 3. | 0.571 |
IL2 | Tlr4 | G3HTL8 | G3I192 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.637 |
IL2 | Tlr6 | G3HTL8 | G3INL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | Toll-like receptor. | 0.702 |
Nr1i2 | ABCB1 | G3HAH7 | P21448 | Nuclear receptor subfamily 1 group I member 2. | ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. | 0.474 |
Nr1i2 | Nr1i3 | G3HAH7 | G3HTY9 | Nuclear receptor subfamily 1 group I member 2. | Nuclear receptor subfamily 1 group I member 3-like isoform 1. | 0.443 |
Nr1i3 | Nr1i2 | G3HTY9 | G3HAH7 | Nuclear receptor subfamily 1 group I member 3-like isoform 1. | Nuclear receptor subfamily 1 group I member 2. | 0.443 |
Ocln | IL1B | G3HRV7 | G3I1B0 | Occludin. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.665 |
Ocln | Tjp1 | G3HRV7 | G3H5A7 | Occludin. | Tight junction protein ZO-1. | 0.993 |
Ocln | Tlr4 | G3HRV7 | G3I192 | Occludin. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.729 |
Tjp1 | Ocln | G3H5A7 | G3HRV7 | Tight junction protein ZO-1. | Occludin. | 0.993 |