node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gcg | Ghrl | G3HZV5 | G3GX43 | Seprase; Belongs to the peptidase S9B family. | Appetite-regulating hormone. | 0.923 |
Gcg | Ins | G3HZV5 | G3HXZ8 | Seprase; Belongs to the peptidase S9B family. | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | 0.944 |
Gcg | Lep | G3HZV5 | G3GZ86 | Seprase; Belongs to the peptidase S9B family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.880 |
Gcg | Npy | G3HZV5 | G3H2L2 | Seprase; Belongs to the peptidase S9B family. | Neuropeptide Y. | 0.544 |
Ghrl | Gcg | G3GX43 | G3HZV5 | Appetite-regulating hormone. | Seprase; Belongs to the peptidase S9B family. | 0.923 |
Ghrl | Ins | G3GX43 | G3HXZ8 | Appetite-regulating hormone. | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | 0.976 |
Ghrl | Lep | G3GX43 | G3GZ86 | Appetite-regulating hormone. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.983 |
Ghrl | Npy | G3GX43 | G3H2L2 | Appetite-regulating hormone. | Neuropeptide Y. | 0.933 |
Ghrl | Per2 | G3GX43 | G3I244 | Appetite-regulating hormone. | Period circadian protein-like 2. | 0.433 |
Ghrl | Rln3 | G3GX43 | G3HD06 | Appetite-regulating hormone. | Relaxin-3. | 0.507 |
Ins | Gcg | G3HXZ8 | G3HZV5 | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | Seprase; Belongs to the peptidase S9B family. | 0.944 |
Ins | Ghrl | G3HXZ8 | G3GX43 | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | Appetite-regulating hormone. | 0.976 |
Ins | Lep | G3HXZ8 | G3GZ86 | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.944 |
Ins | Npy | G3HXZ8 | G3H2L2 | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | Neuropeptide Y. | 0.872 |
Ins | Rln3 | G3HXZ8 | G3HD06 | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | Relaxin-3. | 0.478 |
Ins | Sirt1 | G3HXZ8 | G3HAB1 | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | NAD-dependent deacetylase sirtuin-1. | 0.726 |
Lep | Gcg | G3GZ86 | G3HZV5 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Seprase; Belongs to the peptidase S9B family. | 0.880 |
Lep | Ghrl | G3GZ86 | G3GX43 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Appetite-regulating hormone. | 0.983 |
Lep | Ins | G3GZ86 | G3HXZ8 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | 0.944 |
Lep | Npy | G3GZ86 | G3H2L2 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Neuropeptide Y. | 0.943 |