14 items (Cricetulus griseus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
	Sstr2	Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	Samhd1	SAM domain and HD domain-containing protein 1. (670 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Tk1	Thymidine kinase. (234 aa)
	Tk2	Thymidine kinase 2, mitochondrial. (264 aa)
	Mmp9	Matrix metalloproteinase-9. (710 aa)
	Dctpp1	dCTP pyrophosphatase 1. (157 aa)
	Eif4e	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (117 aa)
	Ccna1	Cyclin-A1; Belongs to the cyclin family. (351 aa)
	Dck	Deoxycytidine kinase. (260 aa)
	Rrm1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
	Rrm2	Ribonucleoside-diphosphate reductase subunit M2. (390 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (274 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC6	Ccna1	Q6RUG6	G3HGB6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Cyclin-A1; Belongs to the cyclin family.	0.999
CDC6	Rrm1	Q6RUG6	G3I3B7	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.823
CDC6	Rrm2	Q6RUG6	G3I2K8	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Ribonucleoside-diphosphate reductase subunit M2.	0.702
Ccna1	CDC6	G3HGB6	Q6RUG6	Cyclin-A1; Belongs to the cyclin family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.999
Ccna1	Rrm1	G3HGB6	G3I3B7	Cyclin-A1; Belongs to the cyclin family.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.480
Ccna1	Rrm2	G3HGB6	G3I2K8	Cyclin-A1; Belongs to the cyclin family.	Ribonucleoside-diphosphate reductase subunit M2.	0.648
Ccna1	Samhd1	G3HGB6	G3GXW9	Cyclin-A1; Belongs to the cyclin family.	SAM domain and HD domain-containing protein 1.	0.517
Ccna1	Tk1	G3HGB6	G3H3F8	Cyclin-A1; Belongs to the cyclin family.	Thymidine kinase.	0.473
Dck	Dctpp1	G3I4C0	G3IKR0	Deoxycytidine kinase.	dCTP pyrophosphatase 1.	0.939
Dck	Rrm1	G3I4C0	G3I3B7	Deoxycytidine kinase.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.832
Dck	Rrm2	G3I4C0	G3I2K8	Deoxycytidine kinase.	Ribonucleoside-diphosphate reductase subunit M2.	0.737
Dck	Tk1	G3I4C0	G3H3F8	Deoxycytidine kinase.	Thymidine kinase.	0.790
Dctpp1	Dck	G3IKR0	G3I4C0	dCTP pyrophosphatase 1.	Deoxycytidine kinase.	0.939
Dctpp1	Rrm1	G3IKR0	G3I3B7	dCTP pyrophosphatase 1.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.928
Dctpp1	Rrm2	G3IKR0	G3I2K8	dCTP pyrophosphatase 1.	Ribonucleoside-diphosphate reductase subunit M2.	0.931
Dctpp1	Samhd1	G3IKR0	G3GXW9	dCTP pyrophosphatase 1.	SAM domain and HD domain-containing protein 1.	0.672
Dctpp1	Tk1	G3IKR0	G3H3F8	dCTP pyrophosphatase 1.	Thymidine kinase.	0.402
Dctpp1	Tk2	G3IKR0	G3H661	dCTP pyrophosphatase 1.	Thymidine kinase 2, mitochondrial.	0.556
Il18	Mmp9	G3H2H9	G3H8V1	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Matrix metalloproteinase-9.	0.483
Mmp9	Il18	G3H8V1	G3H2H9	Matrix metalloproteinase-9.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.483