(17 nodes) (2017) Proteins regulating the intercellular transfer and function of P-glycoprotein in multidrug-resistant cancer. network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	Msn	Moesin. (293 aa)
	Cul1	Cullin-1; Belongs to the cullin family. (776 aa)
	Cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	Skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	Rhoa	Transforming protein RhoA. (193 aa)
	Mmp9	Matrix metalloproteinase-9. (710 aa)
	Cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Rab13	Ras-related protein Rab-13. (199 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Rdx	Radixin. (583 aa)
	Ezr	Ezrin. (586 aa)
	Cxcl12	Stromal cell-derived factor 1. (89 aa)
	Rhoc	Rho-related GTP-binding protein RhoC. (193 aa)
	I79_022257	Actin. (98 aa)
	ABCB1	ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1276 aa)
	ICAM1	Intercellular adhesion molecule 1. (527 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcl2	I79_022257	G3HD46	G3IEV3	Apoptosis regulator Bcl-2.	Actin.	0.480
Bcl2	ICAM1	G3HD46	Q9ERF7	Apoptosis regulator Bcl-2.	Intercellular adhesion molecule 1.	0.401
Bcl2	Mmp9	G3HD46	G3H8V1	Apoptosis regulator Bcl-2.	Matrix metalloproteinase-9.	0.608
Cav1	Cav2	G3H9I8	G3H9I7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.998
Cav1	Cav3	G3H9I8	G3H113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.938
Cav1	I79_022257	G3H9I8	G3IEV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Actin.	0.725
Cav1	ICAM1	G3H9I8	Q9ERF7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Intercellular adhesion molecule 1.	0.629
Cav1	Mmp9	G3H9I8	G3H8V1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Matrix metalloproteinase-9.	0.427
Cav1	Rhoa	G3H9I8	G3H8F9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Transforming protein RhoA.	0.755
Cav2	Cav1	G3H9I7	G3H9I8	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.998
Cav2	Cav3	G3H9I7	G3H113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.994
Cav2	I79_022257	G3H9I7	G3IEV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Actin.	0.675
Cav2	Rhoa	G3H9I7	G3H8F9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Transforming protein RhoA.	0.535
Cav3	Cav1	G3H113	G3H9I8	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.938
Cav3	Cav2	G3H113	G3H9I7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.994
Cav3	I79_022257	G3H113	G3IEV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Actin.	0.674
Cav3	Rhoa	G3H113	G3H8F9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Transforming protein RhoA.	0.598
Cul1	Skp1	G3GXG0	G3H2C9	Cullin-1; Belongs to the cullin family.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.999
Cxcl12	ICAM1	G3I6P7	Q9ERF7	Stromal cell-derived factor 1.	Intercellular adhesion molecule 1.	0.485
Cxcl12	Mmp9	G3I6P7	G3H8V1	Stromal cell-derived factor 1.	Matrix metalloproteinase-9.	0.701