(15 nodes) (2018) Effects of a Dipeptidyl Peptidase 4 Inhibitor Sitagliptin on Glycemic Control and Lipoprotein Metabolism in Patients with Type 2 Diabetes Mellitus (GLORIA Trial). network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Large1	Glycosyltransferase-like protein LARGE1. (756 aa)
	Lpl	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (450 aa)
	Hkdc1	Putative hexokinase HKDC1. (925 aa)
	Hk1	Hexokinase-1. (917 aa)
	Hk3	Hexokinase-3. (867 aa)
	Got1	Aspartate aminotransferase. (413 aa)
	Apob	Apolipoprotein B-100. (3537 aa)
	Hk2	Hexokinase-2. (704 aa)
	Got2	Aspartate aminotransferase. (430 aa)
	Gcg	Seprase; Belongs to the peptidase S9B family. (561 aa)
	I79_016618	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (470 aa)
	Adipoq	Adiponectin. (248 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	Apoa2	Apolipoprotein A-II-like protein. (101 aa)
	Apoe	Apolipoprotein E. (313 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipoq	Apob	G3HYG0	G3GZQ0	Adiponectin.	Apolipoprotein B-100.	0.570
Adipoq	Apoe	G3HYG0	G3HPC9	Adiponectin.	Apolipoprotein E.	0.590
Adipoq	Gcg	G3HYG0	G3HZV5	Adiponectin.	Seprase; Belongs to the peptidase S9B family.	0.575
Adipoq	Got1	G3HYG0	G3GZZ0	Adiponectin.	Aspartate aminotransferase.	0.525
Adipoq	Got2	G3HYG0	G3I2Y1	Adiponectin.	Aspartate aminotransferase.	0.495
Adipoq	Ins	G3HYG0	G3HXZ8	Adiponectin.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.932
Adipoq	Lpl	G3HYG0	G3H6V7	Adiponectin.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.610
Apoa2	Apob	G3HTY7	G3GZQ0	Apolipoprotein A-II-like protein.	Apolipoprotein B-100.	0.897
Apoa2	Apoe	G3HTY7	G3HPC9	Apolipoprotein A-II-like protein.	Apolipoprotein E.	0.957
Apoa2	Got2	G3HTY7	G3I2Y1	Apolipoprotein A-II-like protein.	Aspartate aminotransferase.	0.473
Apoa2	Lpl	G3HTY7	G3H6V7	Apolipoprotein A-II-like protein.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.616
Apob	Adipoq	G3GZQ0	G3HYG0	Apolipoprotein B-100.	Adiponectin.	0.570
Apob	Apoa2	G3GZQ0	G3HTY7	Apolipoprotein B-100.	Apolipoprotein A-II-like protein.	0.897
Apob	Apoe	G3GZQ0	G3HPC9	Apolipoprotein B-100.	Apolipoprotein E.	0.985
Apob	Got1	G3GZQ0	G3GZZ0	Apolipoprotein B-100.	Aspartate aminotransferase.	0.436
Apob	Got2	G3GZQ0	G3I2Y1	Apolipoprotein B-100.	Aspartate aminotransferase.	0.525
Apob	Ins	G3GZQ0	G3HXZ8	Apolipoprotein B-100.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.763
Apob	Lpl	G3GZQ0	G3H6V7	Apolipoprotein B-100.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.760
Apoe	Adipoq	G3HPC9	G3HYG0	Apolipoprotein E.	Adiponectin.	0.590
Apoe	Apoa2	G3HPC9	G3HTY7	Apolipoprotein E.	Apolipoprotein A-II-like protein.	0.957