(26 nodes) (2018) Interferon regulatory factor 1 inactivation in human cancer. network (Cricetulus griseus)

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Your Input:
	Cdk1	Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
	Stat2	Signal transducer and activator of transcription. (806 aa)
	Nras	Cold shock domain-containing protein E1. (451 aa)
	CgPICR_018825	Cell division protein kinase 4. (121 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	I79_011712	Signal transducer and activator of transcription. (793 aa)
	E2f1	Transcription factor E2F1. (367 aa)
	Irf6	Interferon regulatory factor 6. (467 aa)
	Tlr9	Toll-like receptor 9. (1239 aa)
	Mdm2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (476 aa)
	Irf4	Interferon regulatory factor 4. (418 aa)
	Ubl3	Ubiquitin-like protein. (117 aa)
	Esr1	Estrogen receptor. (200 aa)
	Ifnar1	Interferon-alpha/beta receptor alpha chain. (483 aa)
	Irf2	Interferon regulatory factor. (349 aa)
	Irf8	Interferon regulatory factor 8. (424 aa)
	Casp8	Caspase-8; Belongs to the peptidase C14A family. (481 aa)
	Ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	I79_020971	Nucleophosmin. (280 aa)
	I79_020948	Interferon regulatory factor 1. (369 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	Isg15	Ubiquitin-like protein ISG15-like protein. (156 aa)
	I79_017574	Caspase-12; Belongs to the peptidase C14A family. (729 aa)
	Stat6	Signal transducer and activator of transcription. (844 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brca1	Ccnd1	G3HM05	A5A422	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.660
Brca1	Cdk1	G3HM05	G3HVL1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.724
Brca1	CgPICR_018825	G3HM05	G3HQ42	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cell division protein kinase 4.	0.663
Brca1	E2f1	G3HM05	G3HAM7	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Transcription factor E2F1.	0.603
Brca1	Esr1	G3HM05	G3GU19	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Estrogen receptor.	0.961
Brca1	Mdm2	G3HM05	G3GY28	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.611
Brca1	Stat1	G3HM05	G3I9F9	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Signal transducer and activator of transcription.	0.602
Brca1	Stat3	G3HM05	G3HLW9	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Signal transducer and activator of transcription.	0.560
Casp8	Ccnd1	B2CMK5	A5A422	Caspase-8; Belongs to the peptidase C14A family.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.567
Casp8	Cdk1	B2CMK5	G3HVL1	Caspase-8; Belongs to the peptidase C14A family.	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.467
Casp8	Esr1	B2CMK5	G3GU19	Caspase-8; Belongs to the peptidase C14A family.	Estrogen receptor.	0.479
Casp8	I79_017574	B2CMK5	G3I2E4	Caspase-8; Belongs to the peptidase C14A family.	Caspase-12; Belongs to the peptidase C14A family.	0.967
Casp8	Mdm2	B2CMK5	G3GY28	Caspase-8; Belongs to the peptidase C14A family.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.469
Casp8	Stat3	B2CMK5	G3HLW9	Caspase-8; Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.501
Casp8	Tlr3	B2CMK5	G3IHU2	Caspase-8; Belongs to the peptidase C14A family.	Toll-like receptor 3.	0.520
Ccnd1	Brca1	A5A422	G3HM05	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.660
Ccnd1	Casp8	A5A422	B2CMK5	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Caspase-8; Belongs to the peptidase C14A family.	0.567
Ccnd1	Cdk1	A5A422	G3HVL1	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.939
Ccnd1	CgPICR_018825	A5A422	G3HQ42	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Cell division protein kinase 4.	0.989
Ccnd1	E2f1	A5A422	G3HAM7	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Transcription factor E2F1.	0.843