(34 nodes) (2018) Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease. network (Cricetulus griseus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	I79_020424	Pyruvate kinase; Belongs to the pyruvate kinase family. (258 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1178 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Tfeb	Transcription factor EB-like protein. (476 aa)
	I79_016908	Hormone-sensitive lipase. (326 aa)
	Ghrl	Appetite-regulating hormone. (100 aa)
	Fgf21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	Gcg	Seprase; Belongs to the peptidase S9B family. (561 aa)
	Adipoq	Adiponectin. (248 aa)
	Pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (822 aa)
	Insr	Insulin receptor. (114 aa)
	I79_014995	Bile acid receptor. (747 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Pdk4	Protein-serine/threonine kinase. (178 aa)
	Cs	Citrate synthase; Belongs to the citrate synthase family. (313 aa)
	Prkacb	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	I79_010801	Bile acid receptor. (352 aa)
	Prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	Pklr	Pyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
	Metrn	Meteorin. (383 aa)
	I79_025031	TBC1 domain family member 1. (232 aa)
	Sirt1	NAD-dependent deacetylase sirtuin-1. (554 aa)
	Hkdc1	Putative hexokinase HKDC1. (925 aa)
	I79_023874	Pyruvate kinase; Belongs to the pyruvate kinase family. (233 aa)
	Hk3	Hexokinase-3. (867 aa)
	Pkm	Pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
	Tfam	Transcription factor A, mitochondrial. (190 aa)
	Mef2a	Myocyte-specific enhancer factor 2A. (496 aa)
	Igf1	Insulin-like growth factor I. (75 aa)
	Hk1	Hexokinase-1. (917 aa)
	I79_023892	TBC1 domain family member 1. (817 aa)
	Mfn2	Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
	Hk2	Hexokinase-2. (704 aa)
	I79_020755	Pyruvate kinase; Belongs to the pyruvate kinase family. (461 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipoq	Fgf21	G3HYG0	G3HZX2	Adiponectin.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.621
Adipoq	Gcg	G3HYG0	G3HZV5	Adiponectin.	Seprase; Belongs to the peptidase S9B family.	0.575
Adipoq	Ghrl	G3HYG0	G3GX43	Adiponectin.	Appetite-regulating hormone.	0.749
Adipoq	I79_016908	G3HYG0	G3I0M0	Adiponectin.	Hormone-sensitive lipase.	0.743
Adipoq	Igf1	G3HYG0	G3H672	Adiponectin.	Insulin-like growth factor I.	0.591
Adipoq	PPARG	G3HYG0	G3HVG0	Adiponectin.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.885
Adipoq	Sirt1	G3HYG0	G3HAB1	Adiponectin.	NAD-dependent deacetylase sirtuin-1.	0.661
Adipoq	Tlr4	G3HYG0	G3I192	Adiponectin.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.485
Cs	Hk1	G3HRP3	G3H6T5	Citrate synthase; Belongs to the citrate synthase family.	Hexokinase-1.	0.500
Cs	Hk2	G3HRP3	G3IGL3	Citrate synthase; Belongs to the citrate synthase family.	Hexokinase-2.	0.589
Cs	Hk3	G3HRP3	G3H184	Citrate synthase; Belongs to the citrate synthase family.	Hexokinase-3.	0.522
Cs	Hkdc1	G3HRP3	G3H6T6	Citrate synthase; Belongs to the citrate synthase family.	Putative hexokinase HKDC1.	0.522
Cs	PC	G3HRP3	G3I4L6	Citrate synthase; Belongs to the citrate synthase family.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.978
Cs	Pdk4	G3HRP3	G3HT90	Citrate synthase; Belongs to the citrate synthase family.	Protein-serine/threonine kinase.	0.405
Fgf21	Adipoq	G3HZX2	G3HYG0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Adiponectin.	0.621
Fgf21	Igf1	G3HZX2	G3H672	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin-like growth factor I.	0.715
Fgf21	Insr	G3HZX2	G3HWV6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin receptor.	0.739
Fgf21	PPARG	G3HZX2	G3HVG0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.552
Fgf21	Sirt1	G3HZX2	G3HAB1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	NAD-dependent deacetylase sirtuin-1.	0.530
Gcg	Adipoq	G3HZV5	G3HYG0	Seprase; Belongs to the peptidase S9B family.	Adiponectin.	0.575