(37 nodes) (2018) The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation. network (Cricetulus griseus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	Ghrh	Somatoliberin. (102 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Trh	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (247 aa)
	Hkdc1	Putative hexokinase HKDC1. (925 aa)
	Hk1	Hexokinase-1. (917 aa)
	Igf1	Insulin-like growth factor I. (75 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Npy	Neuropeptide Y. (148 aa)
	Hk3	Hexokinase-3. (867 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	ICAM1	Intercellular adhesion molecule 1. (527 aa)
	Tlr6	Toll-like receptor. (795 aa)
	Irs2	Insulin receptor substrate 2. (465 aa)
	Ptges	Prostaglandin E synthase. (150 aa)
	Hk2	Hexokinase-2. (704 aa)
	CgPICR_017379	Toll-like receptor 11. (916 aa)
	Pthlh	Parathyroid hormone-related protein. (191 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1178 aa)
	I79_018056	Prolactin-3D4. (83 aa)
	CgPICR_009833	Prolactin-3B1. (216 aa)
	I79_018053	Prolactin-3B1. (114 aa)
	I79_018051	Prolactin. (225 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	I79_016908	Hormone-sensitive lipase. (326 aa)
	CgPICR_005625	Agouti-related protein. (131 aa)
	I79_015980	Leptin receptor. (533 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	Insr	Insulin receptor. (114 aa)
	Pdk4	Protein-serine/threonine kinase. (178 aa)
	I79_011937	Prolactin-5A1. (252 aa)
	Gck	Phosphotransferase. (465 aa)
	Igfbp1	Insulin-like growth factor-binding protein 1. (272 aa)
	Tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	Pttg1	Securin. (200 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Il10	Interleukin-10. (178 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcl2	Cd4	G3HD46	G3GUN9	Apoptosis regulator Bcl-2.	T-cell surface glycoprotein CD4.	0.574
Bcl2	ICAM1	G3HD46	Q9ERF7	Apoptosis regulator Bcl-2.	Intercellular adhesion molecule 1.	0.401
Bcl2	Ifng	G3HD46	G3GY20	Apoptosis regulator Bcl-2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.478
Bcl2	Igf1	G3HD46	G3H672	Apoptosis regulator Bcl-2.	Insulin-like growth factor I.	0.440
Bcl2	Il10	G3HD46	G3HB01	Apoptosis regulator Bcl-2.	Interleukin-10.	0.500
Bcl2	Ins	G3HD46	G3HXZ8	Apoptosis regulator Bcl-2.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.503
Cd4	Bcl2	G3GUN9	G3HD46	T-cell surface glycoprotein CD4.	Apoptosis regulator Bcl-2.	0.574
Cd4	CgPICR_017379	G3GUN9	G3IFP1	T-cell surface glycoprotein CD4.	Toll-like receptor 11.	0.833
Cd4	ICAM1	G3GUN9	Q9ERF7	T-cell surface glycoprotein CD4.	Intercellular adhesion molecule 1.	0.864
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Igf1	G3GUN9	G3H672	T-cell surface glycoprotein CD4.	Insulin-like growth factor I.	0.589
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Ins	G3GUN9	G3HXZ8	T-cell surface glycoprotein CD4.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.835
Cd4	Lep	G3GUN9	G3GZ86	T-cell surface glycoprotein CD4.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.686
Cd4	Tlr4	G3GUN9	G3I192	T-cell surface glycoprotein CD4.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.914
Cd4	Tlr6	G3GUN9	G3INL2	T-cell surface glycoprotein CD4.	Toll-like receptor.	0.880
CgPICR_005625	Gck	G3HZM4	G3HMA6	Agouti-related protein.	Phosphotransferase.	0.415
CgPICR_005625	Ghrh	G3HZM4	G3GXX5	Agouti-related protein.	Somatoliberin.	0.791
CgPICR_005625	I79_015980	G3HZM4	G3HY62	Agouti-related protein.	Leptin receptor.	0.776
CgPICR_005625	Ins	G3HZM4	G3HXZ8	Agouti-related protein.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.784