STRINGSTRING
Stat3 Stat3 Ccnd1 Ccnd1 Esr1 Esr1 Fasn Fasn Lep Lep Map1a Map1a Hk3 Hk3 I79_004151 I79_004151 Map1s Map1s Ipmk Ipmk Lgr5 Lgr5 Igf1 Igf1 Hk1 Hk1 Hkdc1 Hkdc1 Smad3 Smad3 I79_009594 I79_009594 I79_009796 I79_009796 Vim Vim Map1b Map1b Cdkn1a Cdkn1a Igf1r Igf1r Cdh1 Cdh1 Becn1 Becn1 Ca9 Ca9 I79_012135 I79_012135 Zeb1 Zeb1 Snai2 Snai2 I79_014914 I79_014914 I79_015109 I79_015109 Ins Ins I79_016240 I79_016240 Gcg Gcg Ddit4 Ddit4 Cpa6 Cpa6 Ccn2 Ccn2 Hk2 Hk2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Stat3Signal transducer and activator of transcription. (770 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Esr1Estrogen receptor. (200 aa)
FasnFatty acid synthase. (2503 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Map1aMicrotubule-associated protein 1A. (2585 aa)
Hk3Hexokinase-3. (867 aa)
I79_004151Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (242 aa)
Map1sMicrotubule-associated protein 1S. (870 aa)
IpmkKinase; Belongs to the inositol phosphokinase (IPK) family. (322 aa)
Lgr5Leucine-rich repeat-containing G-protein coupled receptor 5. (555 aa)
Igf1Insulin-like growth factor I. (75 aa)
Hk1Hexokinase-1. (917 aa)
Hkdc1Putative hexokinase HKDC1. (925 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
I79_009594Nestin; Belongs to the intermediate filament family. (1800 aa)
I79_009796Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily. (697 aa)
VimVimentin; Belongs to the intermediate filament family. (466 aa)
Map1bMicrotubule-associated protein 1B. (2371 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (163 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
Cdh1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
Becn1Beclin-1. (448 aa)
Ca9Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (182 aa)
I79_012135Carbonic anhydrase 9. (114 aa)
Zeb1Zinc finger E-box-binding homeobox 1. (1078 aa)
Snai2Zinc finger protein SNAI2-like protein. (268 aa)
I79_014914Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. (756 aa)
I79_015109Interleukin-6. (174 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
I79_016240Beclin-1. (119 aa)
GcgSeprase; Belongs to the peptidase S9B family. (561 aa)
Ddit4DNA-damage-inducible transcript 4 protein. (231 aa)
Cpa6Carboxypeptidase A6. (208 aa)
Ccn2Connective tissue growth factor-like protein. (348 aa)
Hk2Hexokinase-2. (704 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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