12 items (Cricetulus griseus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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gene neighborhood

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Your Input:
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	I79_025220	Serum albumin. (186 aa)
	Alb	Serum albumin. (430 aa)
	Tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	Il10	Interleukin-10. (178 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Tlr9	Toll-like receptor 9. (1239 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Tlr5	Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alb	Cd4	G3IAL6	G3GUN9	Serum albumin.	T-cell surface glycoprotein CD4.	0.860
Alb	I79_025220	G3IAL6	G3IMS5	Serum albumin.	Serum albumin.	0.960
Alb	IL2	G3IAL6	G3HTL8	Serum albumin.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.547
Alb	Ifng	G3IAL6	G3GY20	Serum albumin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.749
Alb	Il10	G3IAL6	G3HB01	Serum albumin.	Interleukin-10.	0.655
Alb	Tlr4	G3IAL6	G3I192	Serum albumin.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.551
Cd4	Alb	G3GUN9	G3IAL6	T-cell surface glycoprotein CD4.	Serum albumin.	0.860
Cd4	I79_025220	G3GUN9	G3IMS5	T-cell surface glycoprotein CD4.	Serum albumin.	0.860
Cd4	IL2	G3GUN9	G3HTL8	T-cell surface glycoprotein CD4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.974
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Il18	G3GUN9	G3H2H9	T-cell surface glycoprotein CD4.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.886
Cd4	Myd88	G3GUN9	G3HQV3	T-cell surface glycoprotein CD4.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.879
Cd4	Tlr4	G3GUN9	G3I192	T-cell surface glycoprotein CD4.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.914
Cd4	Tlr5	G3GUN9	G3GRB7	T-cell surface glycoprotein CD4.	Toll-like receptor 5; Belongs to the Toll-like receptor family.	0.784
Cd4	Tlr7	G3GUN9	G3I9Z2	T-cell surface glycoprotein CD4.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.912
Cd4	Tlr9	G3GUN9	G3GZG1	T-cell surface glycoprotein CD4.	Toll-like receptor 9.	0.889
I79_025220	Alb	G3IMS5	G3IAL6	Serum albumin.	Serum albumin.	0.960
I79_025220	Cd4	G3IMS5	G3GUN9	Serum albumin.	T-cell surface glycoprotein CD4.	0.860
I79_025220	IL2	G3IMS5	G3HTL8	Serum albumin.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.544