(37 nodes) (2018) Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3KAktGSK-3beta signalling pathway in oral cancer. network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	I79_021949	Caspase-3; Belongs to the peptidase C14A family. (195 aa)
	CgPICR_012401	Glyceraldehyde-3-phosphate dehydrogenase. (75 aa)
	CgPICR_009887	Histone H2B; Belongs to the histone H2B family. (126 aa)
	Alb	Serum albumin. (430 aa)
	I79_020089	Caspase-9; Belongs to the peptidase C14A family. (689 aa)
	I79_018057	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	CgPICR_017546	Glyceraldehyde-3-phosphate dehydrogenase. (127 aa)
	CgPICR_002995	Glyceraldehyde-3-phosphate dehydrogenase. (206 aa)
	CgPICR_017739	Glyceraldehyde-3-phosphate dehydrogenase. (163 aa)
	I79_016240	Beclin-1. (119 aa)
	Pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (822 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (147 aa)
	I79_012822	Histone H2B; Belongs to the histone H2B family. (126 aa)
	CgPICR_013910	Glyceraldehyde-3-phosphate dehydrogenase. (104 aa)
	Becn1	Beclin-1. (448 aa)
	CgPICR_000709	Glyceraldehyde-3-phosphate dehydrogenase. (148 aa)
	CgPICR_000710	Glyceraldehyde-3-phosphate dehydrogenase. (129 aa)
	CgPICR_020194	Glyceraldehyde-3-phosphate dehydrogenase. (105 aa)
	I79_010992	Histone H2B type 1; Belongs to the histone H2B family. (126 aa)
	CgPICR_002764	Glyceraldehyde-3-phosphate dehydrogenase. (77 aa)
	Hdac2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
	I79_008720	Histone H2B; Belongs to the histone H2B family. (127 aa)
	I79_008709	Histone H2B; Belongs to the histone H2B family. (126 aa)
	CgPICR_009874	Histone H2B; Belongs to the histone H2B family. (126 aa)
	I79_008696	Histone H2B; Belongs to the histone H2B family. (139 aa)
	I79_008690	Histone H2B; Belongs to the histone H2B family. (67 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
	CgPICR_014458	Histone H2B; Belongs to the histone H2B family. (126 aa)
	CgPICR_014462	Histone H2B; Belongs to the histone H2B family. (126 aa)
	I79_004417	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	I79_001600	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	CgPICR_008588	Glyceraldehyde-3-phosphate dehydrogenase. (161 aa)
	I79_025220	Serum albumin. (186 aa)
	I79_025665	Histone H2B; Belongs to the histone H2B family. (126 aa)
	H671_2g5756	Histone H2B subacrosomal variant-like protein; Belongs to the histone H2B family. (121 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alb	Bcl2	G3IAL6	G3HD46	Serum albumin.	Apoptosis regulator Bcl-2.	0.402
Alb	CgPICR_000709	G3IAL6	G3HKA4	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_000710	G3IAL6	G3HKA3	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_002764	G3IAL6	G3HJV9	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_002995	G3IAL6	G3HZA8	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.695
Alb	CgPICR_008588	G3IAL6	G3IHS0	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_012401	G3IAL6	G3ID55	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_013910	G3IAL6	G3HN28	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_017546	G3IAL6	G3I044	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_017739	G3IAL6	G3HYZ4	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.709
Alb	CgPICR_020194	G3IAL6	G3HK68	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.695
Alb	I79_001600	G3IAL6	G3GV69	Serum albumin.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.618
Alb	I79_004417	G3IAL6	G3H2K2	Serum albumin.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.618
Alb	I79_018057	G3IAL6	G3I3P7	Serum albumin.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.618
Alb	I79_020089	G3IAL6	G3I954	Serum albumin.	Caspase-9; Belongs to the peptidase C14A family.	0.446
Alb	I79_021949	G3IAL6	G3IE08	Serum albumin.	Caspase-3; Belongs to the peptidase C14A family.	0.695
Alb	I79_025220	G3IAL6	G3IMS5	Serum albumin.	Serum albumin.	0.960
Atg5	Bcl2	G3HVR2	G3HD46	Autophagy protein 5; Involved in autophagic vesicle formation.	Apoptosis regulator Bcl-2.	0.612
Atg5	Becn1	G3HVR2	G3HLZ1	Autophagy protein 5; Involved in autophagic vesicle formation.	Beclin-1.	0.955
Atg5	I79_001600	G3HVR2	G3GV69	Autophagy protein 5; Involved in autophagic vesicle formation.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.581