STRINGSTRING
CgPICR_014700 CgPICR_014700 Hus1 Hus1 Jak1 Jak1 I79_016003 I79_016003 Arid1a Arid1a Nrp1 Nrp1 Tlr4 Tlr4 IL1B IL1B Cd80 Cd80 I79_017574 I79_017574 Tab1 Tab1 Sun2 Sun2 Hras Hras Isg15 Isg15 Sox10 Sox10 Bche Bche Top2a Top2a Ccr7 Ccr7 Cxcl12 Cxcl12 Gas6 Gas6 Ccl5 Ccl5 Irx2 Irx2 Xiap Xiap Stat1 Stat1 Tlr7 Tlr7 Alb Alb Enpp1 Enpp1 I79_021151 I79_021151 Cd34 Cd34 I79_021949 I79_021949 Fth1 Fth1 Mad2l1 Mad2l1 Jak2 Jak2 I79_022257 I79_022257 CgPICR_019721 CgPICR_019721 S1pr1 S1pr1 Csf1 Csf1 Tlr3 Tlr3 Arrb1 Arrb1 CgPICR_006550 CgPICR_006550 Ptch1 Ptch1 I79_024975 I79_024975 Cxcr2 Cxcr2 I79_025220 I79_025220 I79_025221 I79_025221 I79_025433 I79_025433 I79_025496 I79_025496 I79_025497 I79_025497 I79_025518 I79_025518 I79_025535 I79_025535 Egr2 Egr2 I79_025726 I79_025726 Acly Acly I79_026231 I79_026231 ICAM1 ICAM1 I79_000092 I79_000092 Adam10 Adam10 Ccnb2 Ccnb2 Irf8 Irf8 CgPICR_014087 CgPICR_014087 Ifnar1 Ifnar1 I79_001024 I79_001024 Cd4 Cd4 Cd163 Cd163 Wnt5a Wnt5a Eomes Eomes Hus1b Hus1b Fasn Fasn Mdm2 Mdm2 Cd68 Cd68 Acadvl Acadvl Rag2 Rag2 Lep Lep Cxcr4 Cxcr4 Mertk Mertk Cd83 Cd83 Edn1 Edn1 Nog Nog Il18 Il18 Akt1 Akt1 Kras Kras I79_005484 I79_005484 Slamf7 Slamf7 Smad3 Smad3 Cd40 Cd40 Nktr Nktr Msln Msln Pole Pole Calr Calr Cd47 Cd47 I79_008519 I79_008519 Egr1 Egr1 Stk11 Stk11 Fos Fos Tgfb3 Tgfb3 I79_009594 I79_009594 Sema4a Sema4a Ace Ace Neil3 Neil3 Cgas Cgas H671_3g8622 H671_3g8622 Ccl22 Ccl22 Cx3cl1 Cx3cl1 Ccl17 Ccl17 Il15 Il15 Pak4 Pak4 Stat3 Stat3 Brca1 Brca1 Brca2 Brca2 Melk Melk Foxp3 Foxp3 Hdac6 Hdac6 Tbp Tbp Cttn Cttn Myd88 Myd88 Cx3cr1 Cx3cr1 I79_013907 I79_013907 Bambi Bambi Idh1 Idh1 Sun1 Sun1 Mzb1 Mzb1 Cmklr1 Cmklr1 Xcr1 Xcr1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CgPICR_014700C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
Hus1Checkpoint protein; Belongs to the HUS1 family. (281 aa)
Jak1Tyrosine-protein kinase. (1140 aa)
I79_016003Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (215 aa)
Arid1aAT-rich interactive domain-containing protein 1A. (1892 aa)
Nrp1Neuropilin; Belongs to the neuropilin family. (923 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
Cd80T-lymphocyte activation antigen CD80. (177 aa)
I79_017574Caspase-12; Belongs to the peptidase C14A family. (729 aa)
Tab1Mitogen-activated protein kinase kinase kinase 7-interacting protein 1. (336 aa)
Sun2Protein unc-84-like B. (730 aa)
HrasGTPase HRas-like protein. (189 aa)
Isg15Ubiquitin-like protein ISG15-like protein. (156 aa)
Sox10Transcription factor SOX-10. (466 aa)
BcheCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (507 aa)
Top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1526 aa)
Ccr7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
Cxcl12Stromal cell-derived factor 1. (89 aa)
Gas6Growth arrest-specific protein 6. (684 aa)
Ccl5C-C motif chemokine. (91 aa)
Irx2Iroquois-class homeodomain protein IRX-2. (211 aa)
XiapBaculoviral IAP repeat-containing protein 4. (441 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
Tlr7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
AlbSerum albumin. (430 aa)
Enpp1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
I79_021151Ephrin-B2. (178 aa)
Cd34Hematopoietic progenitor cell antigen CD34. (383 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
Fth1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (186 aa)
Mad2l1Mitotic spindle assembly checkpoint protein MAD2A-like protein. (205 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_022257Actin. (98 aa)
CgPICR_019721Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (215 aa)
S1pr1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
Csf1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (552 aa)
Tlr3Toll-like receptor 3. (164 aa)
Arrb1Beta-arrestin-1. (422 aa)
CgPICR_006550Interferon-induced protein with tetratricopeptide repeats 1. (410 aa)
Ptch1Protein patched-like 1. (1114 aa)
I79_024975Ephrin-B2. (148 aa)
Cxcr2High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family. (359 aa)
I79_025220Serum albumin. (186 aa)
I79_025221Alpha-fetoprotein. (455 aa)
I79_025433Ephrin-B2; Belongs to the ephrin family. (70 aa)
I79_025496Ephrin-B2. (147 aa)
I79_025497Ephrin-B2; Belongs to the ephrin family. (69 aa)
I79_025518Ephrin-B2. (123 aa)
I79_025535Ephrin-B2. (125 aa)
Egr2Early growth response protein 2. (410 aa)
I79_025726Ephrin-B2. (121 aa)
AclyATP-citrate synthase. (59 aa)
I79_026231Ephrin-B2; Belongs to the ephrin family. (68 aa)
ICAM1Intercellular adhesion molecule 1. (527 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
Adam10Disintegrin and metalloproteinase domain-containing protein 10. (675 aa)
Ccnb2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa)
Irf8Interferon regulatory factor 8. (424 aa)
CgPICR_014087Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (215 aa)
Ifnar1Interferon-alpha/beta receptor alpha chain. (483 aa)
I79_001024Ephrin-B2; Belongs to the ephrin family. (373 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
Cd163Scavenger receptor cysteine-rich type 1 protein M130. (497 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
EomesEomesodermin-like. (446 aa)
Hus1bCheckpoint protein; Belongs to the HUS1 family. (277 aa)
FasnFatty acid synthase. (2503 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (476 aa)
Cd68Macrosialin. (294 aa)
AcadvlVery long-chain specific acyl-CoA dehydrogenase, mitochondrial. (652 aa)
Rag2V(D)J recombination-activating protein 2. (527 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Cxcr4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (290 aa)
MertkProto-oncogene tyrosine-protein kinase MER. (305 aa)
Cd83CD83 antigen. (202 aa)
Edn1Endothelin-1. (202 aa)
NogNoggin. (117 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KrasGTPase KRas. (155 aa)
I79_005484Ferritin heavy chain; Belongs to the universal ribosomal protein uS5 family. (361 aa)
Slamf7SLAM family member 7. (150 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
Cd40Tumor necrosis factor receptor superfamily member 5. (118 aa)
NktrNK-tumor recognition protein. (1158 aa)
MslnMesothelin. (335 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2174 aa)
CalrCalreticulin. (417 aa)
Cd47Leukocyte surface antigen CD47. (268 aa)
I79_008519Natural killer cell protease 1; Belongs to the peptidase S1 family. (262 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
Stk11Serine/threonine-protein kinase 11. (505 aa)
FosProto-oncogene protein c-fos. (381 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
I79_009594Nestin; Belongs to the intermediate filament family. (1800 aa)
Sema4aSemaphorin-4A; Belongs to the semaphorin family. (761 aa)
AceAngiotensin-converting enzyme. (791 aa)
Neil3Endonuclease VIII-like 3. (606 aa)
CgasUncharacterized protein C6orf150. (512 aa)
H671_3g8622Semaphorin-4D; Belongs to the semaphorin family. (833 aa)
Ccl22C-C motif chemokine. (93 aa)
Cx3cl1Fractalkine. (335 aa)
Ccl17C-C motif chemokine. (93 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
Pak4Non-specific serine/threonine protein kinase. (588 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Brca1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
Brca2Breast cancer type 2 susceptibility protein-like. (3008 aa)
MelkNon-specific serine/threonine protein kinase. (636 aa)
Foxp3Forkhead box protein P3. (428 aa)
Hdac6Histone deacetylase 6. (666 aa)
TbpTATA-box-binding protein. (315 aa)
CttnSrc substrate cortactin. (550 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Cx3cr1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
I79_013907Ephrin-B2. (148 aa)
BambiBMP and activin membrane-bound inhibitor-like. (218 aa)
Idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
Sun1Protein unc-84-like A. (916 aa)
Mzb1Proapoptotic caspase adapter protein. (184 aa)
Cmklr1Chemokine receptor-like 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
Xcr1Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (322 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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