(24 nodes) (2018) Human Metapneumovirus: Mechanisms and Molecular Targets Used by the Virus to Avoid the Immune System. network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	Cxcl1	C-X-C motif chemokine. (101 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Foxo1	Forkhead box protein O1. (469 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Stat2	Signal transducer and activator of transcription. (806 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	Il15	Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
	I79_008519	Natural killer cell protease 1; Belongs to the peptidase S1 family. (262 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Il10	Interleukin-10. (178 aa)
	Mavs	Mitochondrial antiviral-signaling protein. (505 aa)
	Mcl1	Putative induced myeloid leukemia cell differentiation protein Mcl-1 like protein. (120 aa)
	Traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Tlr9	Toll-like receptor 9. (1239 aa)
	Traf5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	Reck	Reversion-inducing cysteine-rich protein with Kazal motifs. (714 aa)
	Tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	Pdcd4	Programmed cell death protein 4. (469 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcl2	Cd4	G3HD46	G3GUN9	Apoptosis regulator Bcl-2.	T-cell surface glycoprotein CD4.	0.574
Bcl2	IL2	G3HD46	G3HTL8	Apoptosis regulator Bcl-2.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.467
Bcl2	Ifng	G3HD46	G3GY20	Apoptosis regulator Bcl-2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.478
Bcl2	Il10	G3HD46	G3HB01	Apoptosis regulator Bcl-2.	Interleukin-10.	0.500
Bcl2	Mcl1	G3HD46	G3H2W9	Apoptosis regulator Bcl-2.	Putative induced myeloid leukemia cell differentiation protein Mcl-1 like protein.	0.883
Bcl2	Stat1	G3HD46	G3I9F9	Apoptosis regulator Bcl-2.	Signal transducer and activator of transcription.	0.474
Cd4	Bcl2	G3GUN9	G3HD46	T-cell surface glycoprotein CD4.	Apoptosis regulator Bcl-2.	0.574
Cd4	Cxcl1	G3GUN9	G3I473	T-cell surface glycoprotein CD4.	C-X-C motif chemokine.	0.818
Cd4	Foxo1	G3GUN9	G3HZV8	T-cell surface glycoprotein CD4.	Forkhead box protein O1.	0.477
Cd4	I79_008519	G3GUN9	G3HDH3	T-cell surface glycoprotein CD4.	Natural killer cell protease 1; Belongs to the peptidase S1 family.	0.926
Cd4	IL2	G3GUN9	G3HTL8	T-cell surface glycoprotein CD4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.974
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Il15	G3GUN9	G3HJ60	T-cell surface glycoprotein CD4.	Interleukin; Belongs to the IL-15/IL-21 family.	0.915
Cd4	Mavs	G3GUN9	G3H421	T-cell surface glycoprotein CD4.	Mitochondrial antiviral-signaling protein.	0.489
Cd4	Mtor	G3GUN9	G3IEE8	T-cell surface glycoprotein CD4.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.565
Cd4	Myd88	G3GUN9	G3HQV3	T-cell surface glycoprotein CD4.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.879
Cd4	Stat1	G3GUN9	G3I9F9	T-cell surface glycoprotein CD4.	Signal transducer and activator of transcription.	0.893
Cd4	Stat2	G3GUN9	G3HRN9	T-cell surface glycoprotein CD4.	Signal transducer and activator of transcription.	0.804
Cd4	Tlr3	G3GUN9	G3IHU2	T-cell surface glycoprotein CD4.	Toll-like receptor 3.	0.905