STRINGSTRING
I79_022257 I79_022257 Traf2 Traf2 Mthfr Mthfr I79_023874 I79_023874 Cth Cth Gpx1 Gpx1 Gpx3 Gpx3 Pkm Pkm Ckb Ckb I79_004417 I79_004417 Ckmt1b Ckmt1b DNAJB9 DNAJB9 Traf6 Traf6 Gpx7 Gpx7 I79_001600 I79_001600 I79_022161 I79_022161 I79_021949 I79_021949 Irs1 Irs1 I79_021577 I79_021577 Gpx8 Gpx8 I79_020755 I79_020755 I79_020424 I79_020424 I79_020089 I79_020089 HSPA5 HSPA5 CgPICR_017317 CgPICR_017317 I79_018057 I79_018057 I79_016980 I79_016980 Dmd Dmd Sod2 Sod2 PPARG PPARG Gpx5 Gpx5 Gpx6 Gpx6 Xbp1 Xbp1 Cbs Cbs Ccna1 Ccna1 I79_009215 I79_009215 Bcl2 Bcl2 Prdx2 Prdx2 Pklr Pklr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_022257Actin. (98 aa)
Traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MthfrMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (644 aa)
I79_023874Pyruvate kinase; Belongs to the pyruvate kinase family. (233 aa)
CthCystathionine gamma-lyase. (423 aa)
Gpx1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
Gpx3Glutathione peroxidase 3. (53 aa)
PkmPyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
CkbCreatine kinase B-type; Belongs to the ATP:guanido phosphotransferase family. (203 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Ckmt1bCreatine kinase U-type, mitochondrial; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
DNAJB9DnaJ homolog subfamily B member 9; Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-ass [...] (222 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
Gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
I79_022161Dystrophin. (655 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
Irs1Insulin receptor substrate 1. (1233 aa)
I79_021577Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
Gpx8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
I79_020755Pyruvate kinase; Belongs to the pyruvate kinase family. (461 aa)
I79_020424Pyruvate kinase; Belongs to the pyruvate kinase family. (258 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
CgPICR_017317Insulin receptor substrate 1. (493 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
I79_016980Dystrophin. (193 aa)
DmdDystrophin. (617 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Gpx5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (192 aa)
Gpx6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
Xbp1X-box binding protein 1 isoform 1. (330 aa)
CbsCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (561 aa)
Ccna1Cyclin-A1; Belongs to the cyclin family. (351 aa)
I79_009215Glutathione peroxidase; Belongs to the glutathione peroxidase family. (199 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
Prdx2Peroxiredoxin-2. (198 aa)
PklrPyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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