(19 nodes) (2018) Improving Immunotherapy Through Glycodesign. network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	I79_008000	Mucin-1. (220 aa)
	Man2a1	Alpha-mannosidase. (1099 aa)
	Mgat5	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A. (740 aa)
	Apob	Apolipoprotein B-100. (3537 aa)
	Muc1	Mucin-1. (105 aa)
	Fut8	Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
	I79_009796	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily. (697 aa)
	Slc35a1	CMP-sialic acid transporter. (124 aa)
	Il15	Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	St6gal1	Beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (402 aa)
	I79_016164	P-selectin. (1330 aa)
	I79_018425	Chymotrypsinogen B; Belongs to the peptidase S1 family. (253 aa)
	Epo	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
	Alb	Serum albumin. (430 aa)
	Man2a2	Alpha-mannosidase. (1149 aa)
	I79_025220	Serum albumin. (186 aa)
	Ifnb1	Interferon beta. (182 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alb	Apob	G3IAL6	G3GZQ0	Serum albumin.	Apolipoprotein B-100.	0.657
Alb	Epo	G3IAL6	G3I675	Serum albumin.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.444
Alb	I79_009796	G3IAL6	G3HGQ6	Serum albumin.	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.831
Alb	I79_016164	G3IAL6	G3HYM3	Serum albumin.	P-selectin.	0.460
Alb	I79_018425	G3IAL6	G3I4P2	Serum albumin.	Chymotrypsinogen B; Belongs to the peptidase S1 family.	0.545
Alb	I79_025220	G3IAL6	G3IMS5	Serum albumin.	Serum albumin.	0.960
Alb	Ifng	G3IAL6	G3GY20	Serum albumin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.749
Alb	Il15	G3IAL6	G3HJ60	Serum albumin.	Interleukin; Belongs to the IL-15/IL-21 family.	0.415
Alb	Ins	G3IAL6	G3HXZ8	Serum albumin.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.879
Apob	Alb	G3GZQ0	G3IAL6	Apolipoprotein B-100.	Serum albumin.	0.657
Apob	I79_009796	G3GZQ0	G3HGQ6	Apolipoprotein B-100.	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.868
Apob	I79_025220	G3GZQ0	G3IMS5	Apolipoprotein B-100.	Serum albumin.	0.657
Apob	Ins	G3GZQ0	G3HXZ8	Apolipoprotein B-100.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.763
Epo	Alb	G3I675	G3IAL6	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Serum albumin.	0.444
Epo	I79_025220	G3I675	G3IMS5	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Serum albumin.	0.444
Epo	Ifng	G3I675	G3GY20	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.486
Epo	Ins	G3I675	G3HXZ8	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.557
Fut8	Man2a1	G3HCE4	G3H559	Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family.	Alpha-mannosidase.	0.972
Fut8	Man2a2	G3HCE4	G3IG18	Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family.	Alpha-mannosidase.	0.968
Fut8	Mgat5	G3HCE4	G3GZF3	Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family.	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A.	0.551