(21 nodes) (2018) Proteasomal Protein Degradation: Adaptation of Cellular Proteolysis With Impact on Virus-and Cytokine-Mediated Damage of Heart Tissue During Myocarditis. network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	Cd80	T-lymphocyte activation antigen CD80. (177 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Trex1	Three prime repair exonuclease 1. (320 aa)
	Cgas	Uncharacterized protein C6orf150. (512 aa)
	Cd86	T-lymphocyte activation antigen CD86. (269 aa)
	Cd40	Tumor necrosis factor receptor superfamily member 5. (118 aa)
	Crp	Pentaxin. (225 aa)
	B2m	Beta-2-microglobulin. (54 aa)
	Tlr9	Toll-like receptor 9. (1239 aa)
	Irf8	Interferon regulatory factor 8. (424 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Tlr6	Toll-like receptor. (795 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	CgPICR_017379	Toll-like receptor 11. (916 aa)
	Tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
	Tlr8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1027 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	Ccr7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	Isg15	Ubiquitin-like protein ISG15-like protein. (156 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2m	Cd4	G3H0S7	G3GUN9	Beta-2-microglobulin.	T-cell surface glycoprotein CD4.	0.789
B2m	Cd80	G3H0S7	G3I1J7	Beta-2-microglobulin.	T-lymphocyte activation antigen CD80.	0.520
B2m	Ifng	G3H0S7	G3GY20	Beta-2-microglobulin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.521
B2m	Isg15	G3H0S7	G3I436	Beta-2-microglobulin.	Ubiquitin-like protein ISG15-like protein.	0.568
B2m	Stat1	G3H0S7	G3I9F9	Beta-2-microglobulin.	Signal transducer and activator of transcription.	0.475
Ccr7	Cd4	G3I5N8	G3GUN9	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-cell surface glycoprotein CD4.	0.922
Ccr7	Cd40	G3I5N8	G3H8U5	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Tumor necrosis factor receptor superfamily member 5.	0.684
Ccr7	Cd80	G3I5N8	G3I1J7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-lymphocyte activation antigen CD80.	0.752
Ccr7	Cd86	G3I5N8	G3HAJ6	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-lymphocyte activation antigen CD86.	0.747
Ccr7	Ifng	G3I5N8	G3GY20	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.761
Ccr7	Stat1	G3I5N8	G3I9F9	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Signal transducer and activator of transcription.	0.406
Ccr7	Tlr9	G3I5N8	G3GZG1	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Toll-like receptor 9.	0.418
Cd4	B2m	G3GUN9	G3H0S7	T-cell surface glycoprotein CD4.	Beta-2-microglobulin.	0.789
Cd4	Ccr7	G3GUN9	G3I5N8	T-cell surface glycoprotein CD4.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.922
Cd4	Cd40	G3GUN9	G3H8U5	T-cell surface glycoprotein CD4.	Tumor necrosis factor receptor superfamily member 5.	0.949
Cd4	Cd80	G3GUN9	G3I1J7	T-cell surface glycoprotein CD4.	T-lymphocyte activation antigen CD80.	0.964
Cd4	Cd86	G3GUN9	G3HAJ6	T-cell surface glycoprotein CD4.	T-lymphocyte activation antigen CD86.	0.955
Cd4	CgPICR_017379	G3GUN9	G3IFP1	T-cell surface glycoprotein CD4.	Toll-like receptor 11.	0.833
Cd4	Cgas	G3GUN9	G3HH41	T-cell surface glycoprotein CD4.	Uncharacterized protein C6orf150.	0.737
Cd4	Crp	G3GUN9	G3H7Z7	T-cell surface glycoprotein CD4.	Pentaxin.	0.734