STRINGSTRING
Ccnd1 Ccnd1 Casp8 Casp8 I79_001600 I79_001600 Gpx7 Gpx7 Mylk4 Mylk4 Src Src Ifng Ifng Ctsb Ctsb Hk3 Hk3 I79_004417 I79_004417 Cdc25b Cdc25b Gpx3 Gpx3 Hk1 Hk1 Hkdc1 Hkdc1 Ripk1 Ripk1 I79_021949 I79_021949 Irs1 Irs1 Gpx1 Gpx1 Hdac1 Hdac1 Bcl2 Bcl2 I79_009215 I79_009215 Hprt1 Hprt1 Hdac2 Hdac2 Hdac5 Hdac5 Stat3 Stat3 Hdac6 Hdac6 Gpx6 Gpx6 Gpx5 Gpx5 PPARG PPARG I79_015041 I79_015041 Sod2 Sod2 Hdac4 Hdac4 I79_017574 I79_017574 I79_017768 I79_017768 I79_018057 I79_018057 Gpx8 Gpx8 Alb Alb I79_020089 I79_020089 HSPA5 HSPA5 I79_025220 I79_025220 CgPICR_009695 CgPICR_009695 Hk2 Hk2 Tyms Tyms CgPICR_017317 CgPICR_017317
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Casp8Caspase-8; Belongs to the peptidase C14A family. (481 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
Mylk4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (318 aa)
SrcTyrosine-protein kinase. (536 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
CtsbCathepsin B; Belongs to the peptidase C1 family. (339 aa)
Hk3Hexokinase-3. (867 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Cdc25bM-phase inducer phosphatase 2. (480 aa)
Gpx3Glutathione peroxidase 3. (53 aa)
Hk1Hexokinase-1. (917 aa)
Hkdc1Putative hexokinase HKDC1. (925 aa)
Ripk1Receptor-interacting serine/threonine-protein kinase 1. (655 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
Irs1Insulin receptor substrate 1. (1233 aa)
Gpx1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
Hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
I79_009215Glutathione peroxidase; Belongs to the glutathione peroxidase family. (199 aa)
Hprt1Hypoxanthine-guanine phosphoribosyltransferase. (76 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
Hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Hdac6Histone deacetylase 6. (666 aa)
Gpx6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
Gpx5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (192 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
I79_015041Thymidylate synthase. (192 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
I79_017574Caspase-12; Belongs to the peptidase C14A family. (729 aa)
I79_017768Casein kinase II subunit alpha. (322 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
Gpx8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
AlbSerum albumin. (430 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
I79_025220Serum albumin. (186 aa)
CgPICR_009695Cytochrome P450 2E1; Belongs to the cytochrome P450 family. (493 aa)
Hk2Hexokinase-2. (704 aa)
TymsThymidylate synthase-like protein. (307 aa)
CgPICR_017317Insulin receptor substrate 1. (493 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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