9 items (Cricetulus griseus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (822 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	I79_015980	Leptin receptor. (533 aa)
	Adipoq	Adiponectin. (248 aa)
	Gcg	Seprase; Belongs to the peptidase S9B family. (561 aa)
	CgPICR_017317	Insulin receptor substrate 1. (493 aa)
	Irs1	Insulin receptor substrate 1. (1233 aa)
	Irs2	Insulin receptor substrate 2. (465 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipoq	CgPICR_017317	G3HYG0	G3I658	Adiponectin.	Insulin receptor substrate 1.	0.618
Adipoq	Gcg	G3HYG0	G3HZV5	Adiponectin.	Seprase; Belongs to the peptidase S9B family.	0.575
Adipoq	I79_015980	G3HYG0	G3HY62	Adiponectin.	Leptin receptor.	0.702
Adipoq	Ins	G3HYG0	G3HXZ8	Adiponectin.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.932
Adipoq	Irs1	G3HYG0	G3IDC4	Adiponectin.	Insulin receptor substrate 1.	0.651
Adipoq	Irs2	G3HYG0	G3IKD0	Adiponectin.	Insulin receptor substrate 2.	0.534
Adipoq	Lep	G3HYG0	G3GZ86	Adiponectin.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.974
CgPICR_017317	Adipoq	G3I658	G3HYG0	Insulin receptor substrate 1.	Adiponectin.	0.618
CgPICR_017317	Gcg	G3I658	G3HZV5	Insulin receptor substrate 1.	Seprase; Belongs to the peptidase S9B family.	0.503
CgPICR_017317	I79_015980	G3I658	G3HY62	Insulin receptor substrate 1.	Leptin receptor.	0.447
CgPICR_017317	Ins	G3I658	G3HXZ8	Insulin receptor substrate 1.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.996
CgPICR_017317	Irs1	G3I658	G3IDC4	Insulin receptor substrate 1.	Insulin receptor substrate 1.	0.901
CgPICR_017317	Irs2	G3I658	G3IKD0	Insulin receptor substrate 1.	Insulin receptor substrate 2.	0.996
CgPICR_017317	Lep	G3I658	G3GZ86	Insulin receptor substrate 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.657
CgPICR_017317	Pik3c3	G3I658	G3HX36	Insulin receptor substrate 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.652
Gcg	Adipoq	G3HZV5	G3HYG0	Seprase; Belongs to the peptidase S9B family.	Adiponectin.	0.575
Gcg	CgPICR_017317	G3HZV5	G3I658	Seprase; Belongs to the peptidase S9B family.	Insulin receptor substrate 1.	0.503
Gcg	Ins	G3HZV5	G3HXZ8	Seprase; Belongs to the peptidase S9B family.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.944
Gcg	Irs1	G3HZV5	G3IDC4	Seprase; Belongs to the peptidase S9B family.	Insulin receptor substrate 1.	0.503
Gcg	Lep	G3HZV5	G3GZ86	Seprase; Belongs to the peptidase S9B family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.880