(11 nodes) (2019) A way for in vitroex vivo egg production in mammals. network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Foxo3	Forkhead box protein O3. (672 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Kit	Mast/stem cell growth factor receptor. (452 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	Stat6	Signal transducer and activator of transcription. (844 aa)
	Stat2	Signal transducer and activator of transcription. (806 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	I79_011712	Signal transducer and activator of transcription. (793 aa)
	Kitlg	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
	Tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Foxo3	Ins	G3GXK7	G3HXZ8	Forkhead box protein O3.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.506
Foxo3	Stat3	G3GXK7	G3HLW9	Forkhead box protein O3.	Signal transducer and activator of transcription.	0.956
I79_000092	Tgfb3	G3GRE7	G3HFS5	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.722
I79_011712	Ins	G3HLW8	G3HXZ8	Signal transducer and activator of transcription.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.412
I79_011712	Kit	G3HLW8	G3IMP9	Signal transducer and activator of transcription.	Mast/stem cell growth factor receptor.	0.947
I79_011712	Kitlg	G3HLW8	G3HII0	Signal transducer and activator of transcription.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.463
I79_011712	Stat1	G3HLW8	G3I9F9	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.842
I79_011712	Stat2	G3HLW8	G3HRN9	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.831
I79_011712	Stat3	G3HLW8	G3HLW9	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.970
I79_011712	Stat6	G3HLW8	G3HW32	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.762
Ins	Foxo3	G3HXZ8	G3GXK7	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Forkhead box protein O3.	0.506
Ins	I79_011712	G3HXZ8	G3HLW8	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Signal transducer and activator of transcription.	0.412
Ins	Kit	G3HXZ8	G3IMP9	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Mast/stem cell growth factor receptor.	0.935
Ins	Kitlg	G3HXZ8	G3HII0	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.430
Ins	Stat1	G3HXZ8	G3I9F9	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Signal transducer and activator of transcription.	0.444
Ins	Stat2	G3HXZ8	G3HRN9	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Signal transducer and activator of transcription.	0.415
Ins	Stat3	G3HXZ8	G3HLW9	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Signal transducer and activator of transcription.	0.694
Ins	Stat6	G3HXZ8	G3HW32	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Signal transducer and activator of transcription.	0.412
Kit	I79_011712	G3IMP9	G3HLW8	Mast/stem cell growth factor receptor.	Signal transducer and activator of transcription.	0.947
Kit	Ins	G3IMP9	G3HXZ8	Mast/stem cell growth factor receptor.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.935