STRINGSTRING
Bcl2 Bcl2 Ccn2 Ccn2 Hmox1 Hmox1 Tgfb1 Tgfb1 Nox4 Nox4 I79_020089 I79_020089 NOTCH1 NOTCH1 I79_018057 I79_018057 I79_017669 I79_017669 I79_017529 I79_017529 Tlr4 Tlr4 Hnf4a Hnf4a Fgf21 Fgf21 Hif1a Hif1a I79_016240 I79_016240 I79_016164 I79_016164 Mif Mif Ins Ins Insr Insr Sod2 Sod2 PPARG PPARG Myd88 Myd88 Smad7 Smad7 I79_012707 I79_012707 H671_1g2871 H671_1g2871 Apoe Apoe Ccl19 Ccl19 Aebp1 Aebp1 Becn1 Becn1 Stat3 Stat3 Glp1r Glp1r Igf1r Igf1r Skp2 Skp2 Cdc42 Cdc42 Trpv4 Trpv4 I79_010330 I79_010330 H671_xg20748 H671_xg20748 Akr1b1 Akr1b1 I79_009671 I79_009671 Ace Ace I79_009669 I79_009669 Bcl2l1 Bcl2l1 Il10 Il10 Sirt1 Sirt1 Ednra Ednra Mmp9 Mmp9 Lgals3 Lgals3 Lpl Lpl Pcna Pcna Npy Npy I79_004417 I79_004417 Nfe2l2 Nfe2l2 Apob Apob Nr1h3 Nr1h3 Ifng Ifng I79_002178 I79_002178 I79_001600 I79_001600 Cd4 Cd4 I79_001376 I79_001376 Abca1 Abca1 Pcsk9 Pcsk9 Ccnd1 Ccnd1 LDLR LDLR Irs2 Irs2 I79_024172 I79_024172 F3 F3 Traf2 Traf2 Bnip3 Bnip3 Ppara Ppara I79_022390 I79_022390 I79_022257 I79_022257 Jak2 Jak2 I79_021949 I79_021949 Vcam1 Vcam1 I79_021045 I79_021045
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Bcl2Apoptosis regulator Bcl-2. (203 aa)
Ccn2Connective tissue growth factor-like protein. (348 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Nox4NADPH oxidase 4. (130 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
NOTCH1Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2527 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
I79_017669Apoptotic protease-activating factor 1. (434 aa)
I79_017529Apoptotic protease-activating factor 1. (444 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Hnf4aHepatocyte nuclear factor 4-alpha. (464 aa)
Fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
Hif1aHypoxia-inducible factor 1 alpha. (820 aa)
I79_016240Beclin-1. (119 aa)
I79_016164P-selectin. (1330 aa)
MifMacrophage migration inhibitory factor. (115 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
InsrInsulin receptor. (114 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Smad7Mothers against decapentaplegic-like 7. (256 aa)
I79_012707Alpha-amylase. (418 aa)
H671_1g2871Alpha-amylase; Belongs to the glycosyl hydrolase 13 family. (450 aa)
ApoeApolipoprotein E. (313 aa)
Ccl19C-C motif chemokine. (117 aa)
Aebp1Adipocyte enhancer-binding protein 1. (1126 aa)
Becn1Beclin-1. (448 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Glp1rGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (437 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
Skp2S-phase kinase-associated protein 2. (424 aa)
Cdc42Cell division control protein 42-like. (191 aa)
Trpv4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
I79_010330Hepatocyte nuclear factor 1-alpha. (668 aa)
H671_xg20748Angiotensin-converting enzyme. (644 aa)
Akr1b1Aldose reductase. (316 aa)
I79_009671Angiotensin-converting enzyme. (701 aa)
AceAngiotensin-converting enzyme. (791 aa)
I79_009669Angiotensin-converting enzyme. (605 aa)
Bcl2l1Bcl-2-like protein 1. (233 aa)
Il10Interleukin-10. (178 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
EdnraEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
Lgals3Galectin. (281 aa)
LplLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (450 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
NpyNeuropeptide Y. (148 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Nfe2l2Nuclear factor erythroid 2-related factor 2. (588 aa)
ApobApolipoprotein B-100. (3537 aa)
Nr1h3Oxysterols receptor LXR-alpha. (402 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
I79_002178Urokinase-type plasminogen activator; Belongs to the peptidase S1 family. (397 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
I79_001376Von Willebrand factor. (3626 aa)
Abca1ATP-binding cassette sub-family A member 1. (2261 aa)
Pcsk9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (691 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
Irs2Insulin receptor substrate 2. (465 aa)
I79_024172Aldose reductase. (150 aa)
F3Tissue factor. (293 aa)
Traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
Bnip3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (151 aa)
PparaPeroxisome proliferator-activated receptor alpha. (393 aa)
I79_022390Peroxisome proliferator-activated receptor alpha. (110 aa)
I79_022257Actin. (98 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
Vcam1Vascular cell adhesion protein 1. (220 aa)
I79_021045Heme oxygenase 1. (81 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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