(6 nodes) (2019) Toxoplasma gondii: CD8 T Cells Cry for CD4 Help. network (Cricetulus griseus)

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Your Input:
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Irak1	Interleukin-1 receptor-associated kinase 1. (494 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Tlr3	Toll-like receptor 3. (164 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL2	Ifng	G3HTL8	G3GY20	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
IL2	Tlr3	G3HTL8	G3IHU2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Toll-like receptor 3.	0.571
IL2	Tnf	G3HTL8	G3HZG9	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.853
Ifng	IL2	G3GY20	G3HTL8	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.966
Ifng	Irak1	G3GY20	G3HSV4	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-1 receptor-associated kinase 1.	0.529
Ifng	Tlr3	G3GY20	G3IHU2	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Toll-like receptor 3.	0.775
Ifng	Tnf	G3GY20	G3HZG9	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.902
Ifng	Traf6	G3GY20	G3GZ05	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.578
Irak1	Ifng	G3HSV4	G3GY20	Interleukin-1 receptor-associated kinase 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.529
Irak1	Tlr3	G3HSV4	G3IHU2	Interleukin-1 receptor-associated kinase 1.	Toll-like receptor 3.	0.790
Irak1	Tnf	G3HSV4	G3HZG9	Interleukin-1 receptor-associated kinase 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.722
Irak1	Traf6	G3HSV4	G3GZ05	Interleukin-1 receptor-associated kinase 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
Tlr3	IL2	G3IHU2	G3HTL8	Toll-like receptor 3.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.571
Tlr3	Ifng	G3IHU2	G3GY20	Toll-like receptor 3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.775
Tlr3	Irak1	G3IHU2	G3HSV4	Toll-like receptor 3.	Interleukin-1 receptor-associated kinase 1.	0.790
Tlr3	Tnf	G3IHU2	G3HZG9	Toll-like receptor 3.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.658
Tlr3	Traf6	G3IHU2	G3GZ05	Toll-like receptor 3.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.984
Tnf	IL2	G3HZG9	G3HTL8	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.853
Tnf	Ifng	G3HZG9	G3GY20	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.902
Tnf	Irak1	G3HZG9	G3HSV4	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Interleukin-1 receptor-associated kinase 1.	0.722