(10 nodes) (2019) Combating viral contaminants in CHO cells by engineering innate immunity. network (Cricetulus griseus)

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Your Input:
	Il33	Interleukin-33. (217 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Trim24	Transcription intermediary factor 1-alpha. (493 aa)
	Irf8	Interferon regulatory factor 8. (424 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Tlr9	Toll-like receptor 9. (1239 aa)
	Nfatc2	Nuclear factor of activated T-cells, cytoplasmic 2. (602 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Il18	Il33	G3H2H9	G3I4V3	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-33.	0.762
Il18	Stat1	G3H2H9	G3I9F9	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Signal transducer and activator of transcription.	0.573
Il18	Tlr3	G3H2H9	G3IHU2	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Toll-like receptor 3.	0.625
Il18	Tlr4	G3H2H9	G3I192	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.781
Il18	Tlr7	G3H2H9	G3I9Z2	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.548
Il18	Tlr9	G3H2H9	G3GZG1	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Toll-like receptor 9.	0.513
Il33	Il18	G3I4V3	G3H2H9	Interleukin-33.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.762
Il33	Stat1	G3I4V3	G3I9F9	Interleukin-33.	Signal transducer and activator of transcription.	0.515
Il33	Tlr4	G3I4V3	G3I192	Interleukin-33.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.548
Il33	Tlr7	G3I4V3	G3I9Z2	Interleukin-33.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.503
Irf8	Stat1	G3GRW0	G3I9F9	Interferon regulatory factor 8.	Signal transducer and activator of transcription.	0.646
Irf8	Tlr7	G3GRW0	G3I9Z2	Interferon regulatory factor 8.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.442
Nfatc2	Trim24	G3IJ94	G3HH86	Nuclear factor of activated T-cells, cytoplasmic 2.	Transcription intermediary factor 1-alpha.	0.475
Stat1	Il18	G3I9F9	G3H2H9	Signal transducer and activator of transcription.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.573
Stat1	Il33	G3I9F9	G3I4V3	Signal transducer and activator of transcription.	Interleukin-33.	0.515
Stat1	Irf8	G3I9F9	G3GRW0	Signal transducer and activator of transcription.	Interferon regulatory factor 8.	0.646
Stat1	Tlr3	G3I9F9	G3IHU2	Signal transducer and activator of transcription.	Toll-like receptor 3.	0.723
Stat1	Tlr4	G3I9F9	G3I192	Signal transducer and activator of transcription.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.652
Stat1	Tlr7	G3I9F9	G3I9Z2	Signal transducer and activator of transcription.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.659
Stat1	Tlr9	G3I9F9	G3GZG1	Signal transducer and activator of transcription.	Toll-like receptor 9.	0.455