STRINGSTRING
Lyrm9 Lyrm9 Ccnd1 Ccnd1 Casp8 Casp8 I79_000092 I79_000092 Nos1 Nos1 Ntf3 Ntf3 I79_001476 I79_001476 I79_001600 I79_001600 Nr1h3 Nr1h3 I79_004417 I79_004417 Mmp9 Mmp9 I79_007693 I79_007693 Bcl2 Bcl2 Comt Comt Tgfb3 Tgfb3 I79_010155 I79_010155 Il15 Il15 Stat3 Stat3 Hmox2 Hmox2 Gadd45b Gadd45b PPARG PPARG I79_015109 I79_015109 Nqo1 Nqo1 Osm Osm Tlr4 Tlr4 IL1B IL1B I79_018057 I79_018057 Hmox1 Hmox1 Timp1 Timp1 I79_021577 I79_021577 I79_021949 I79_021949 I79_022390 I79_022390 Ppara Ppara I79_023478 I79_023478 Esam Esam ICAM1 ICAM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Lyrm9Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Casp8Caspase-8; Belongs to the peptidase C14A family. (481 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
Ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
I79_001476Collagenase 3. (300 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Nr1h3Oxysterols receptor LXR-alpha. (402 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
I79_007693Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
ComtCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (265 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
I79_010155Sterol regulatory element-binding protein 1. (1050 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Hmox2Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (316 aa)
Gadd45bGrowth arrest and DNA-damage-inducible protein GADD45 beta. (232 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
I79_015109Interleukin-6. (174 aa)
Nqo1NAD(P)H dehydrogenase [quinone] 1. (274 aa)
OsmOncostatin-M. (222 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
Timp1Metalloproteinase inhibitor 1-like protein. (203 aa)
I79_021577Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
I79_022390Peroxisome proliferator-activated receptor alpha. (110 aa)
PparaPeroxisome proliferator-activated receptor alpha. (393 aa)
I79_023478Transmembrane O-methyltransferase. (134 aa)
EsamEndothelial cell-selective adhesion molecule. (590 aa)
ICAM1Intercellular adhesion molecule 1. (527 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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