(25 nodes) (2020) TGF-beta1 Increases GDNF Production by Upregulating the Expression of GDNF and Furin in Human Granulosa-Lutein Cells. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	fur	Furin endoprotease; Belongs to the peptidase S8 family. (794 aa)
	I79_025944	Hyaluronan synthase 2. (151 aa)
	Has2	Hyaluronan synthase 2. (337 aa)
	Acvr1b	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (373 aa)
	CgPICR_008588	Glyceraldehyde-3-phosphate dehydrogenase. (161 aa)
	CgPICR_012401	Glyceraldehyde-3-phosphate dehydrogenase. (75 aa)
	Ccn2	Connective tissue growth factor-like protein. (348 aa)
	Pcsk7	Proprotein convertase subtilisin/kexin type 7. (787 aa)
	CgPICR_017546	Glyceraldehyde-3-phosphate dehydrogenase. (127 aa)
	CgPICR_002995	Glyceraldehyde-3-phosphate dehydrogenase. (206 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Smad3	Mothers against decapentaplegic homolog. (363 aa)
	Smad2	Mothers against decapentaplegic homolog. (467 aa)
	Pxdn	Peroxidasin-like. (1475 aa)
	Bmp7	Bone morphogenetic protein 7. (430 aa)
	Bmp6	Bone morphogenetic protein 6. (296 aa)
	Gdnf	Glial cell line-derived neurotrophic factor. (160 aa)
	CgPICR_002764	Glyceraldehyde-3-phosphate dehydrogenase. (77 aa)
	CgPICR_020194	Glyceraldehyde-3-phosphate dehydrogenase. (105 aa)
	CgPICR_017739	Glyceraldehyde-3-phosphate dehydrogenase. (163 aa)
	Smad4	Mothers against decapentaplegic-like 4. (259 aa)
	CgPICR_013910	Glyceraldehyde-3-phosphate dehydrogenase. (104 aa)
	CgPICR_000709	Glyceraldehyde-3-phosphate dehydrogenase. (148 aa)
	CgPICR_000710	Glyceraldehyde-3-phosphate dehydrogenase. (129 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acvr1b	Bmp6	G3INS5	G3HD96	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 6.	0.448
Acvr1b	Bmp7	G3INS5	G3HBL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 7.	0.457
Acvr1b	I79_000092	G3INS5	G3GRE7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.513
Acvr1b	Smad2	G3INS5	G3HAD0	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.975
Acvr1b	Smad3	G3INS5	G3H8N9	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.971
Acvr1b	Smad4	G3INS5	G3HTR4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic-like 4.	0.752
Acvr1b	Tgfb3	G3INS5	G3HFS5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.642
Bmp6	Acvr1b	G3HD96	G3INS5	Bone morphogenetic protein 6.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.448
Bmp6	Smad2	G3HD96	G3HAD0	Bone morphogenetic protein 6.	Mothers against decapentaplegic homolog.	0.580
Bmp6	Smad3	G3HD96	G3H8N9	Bone morphogenetic protein 6.	Mothers against decapentaplegic homolog.	0.433
Bmp6	Smad4	G3HD96	G3HTR4	Bone morphogenetic protein 6.	Mothers against decapentaplegic-like 4.	0.649
Bmp6	fur	G3HD96	Q60426	Bone morphogenetic protein 6.	Furin endoprotease; Belongs to the peptidase S8 family.	0.400
Bmp7	Acvr1b	G3HBL1	G3INS5	Bone morphogenetic protein 7.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.457
Bmp7	Smad2	G3HBL1	G3HAD0	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.677
Bmp7	Smad3	G3HBL1	G3H8N9	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.602
Bmp7	Smad4	G3HBL1	G3HTR4	Bone morphogenetic protein 7.	Mothers against decapentaplegic-like 4.	0.634
Ccn2	I79_000092	G3IAP3	G3GRE7	Connective tissue growth factor-like protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.404
Ccn2	Pxdn	G3IAP3	G3HBI1	Connective tissue growth factor-like protein.	Peroxidasin-like.	0.408
Ccn2	Smad2	G3IAP3	G3HAD0	Connective tissue growth factor-like protein.	Mothers against decapentaplegic homolog.	0.597
Ccn2	Smad3	G3IAP3	G3H8N9	Connective tissue growth factor-like protein.	Mothers against decapentaplegic homolog.	0.568