(10 nodes) (2019) HBeAg seroconversion is associated with a more effective PD-L1 blockade during chronic hepatitis B infection. network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Il10	Interleukin-10. (178 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Got1	Aspartate aminotransferase. (413 aa)
	Tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Got2	Aspartate aminotransferase. (430 aa)
	I79_022257	Actin. (98 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd4	Got1	G3GUN9	G3GZZ0	T-cell surface glycoprotein CD4.	Aspartate aminotransferase.	0.766
Cd4	Got2	G3GUN9	G3I2Y1	T-cell surface glycoprotein CD4.	Aspartate aminotransferase.	0.786
Cd4	I79_022257	G3GUN9	G3IEV3	T-cell surface glycoprotein CD4.	Actin.	0.604
Cd4	IL2	G3GUN9	G3HTL8	T-cell surface glycoprotein CD4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.974
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Tnf	G3GUN9	G3HZG9	T-cell surface glycoprotein CD4.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.884
Got1	Cd4	G3GZZ0	G3GUN9	Aspartate aminotransferase.	T-cell surface glycoprotein CD4.	0.766
Got1	Got2	G3GZZ0	G3I2Y1	Aspartate aminotransferase.	Aspartate aminotransferase.	0.985
Got1	Ifng	G3GZZ0	G3GY20	Aspartate aminotransferase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.483
Got1	Il10	G3GZZ0	G3HB01	Aspartate aminotransferase.	Interleukin-10.	0.607
Got1	Tnf	G3GZZ0	G3HZG9	Aspartate aminotransferase.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.454
Got2	Cd4	G3I2Y1	G3GUN9	Aspartate aminotransferase.	T-cell surface glycoprotein CD4.	0.786
Got2	Got1	G3I2Y1	G3GZZ0	Aspartate aminotransferase.	Aspartate aminotransferase.	0.985
Got2	Ifng	G3I2Y1	G3GY20	Aspartate aminotransferase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.480
Got2	Il10	G3I2Y1	G3HB01	Aspartate aminotransferase.	Interleukin-10.	0.723
Got2	Tnf	G3I2Y1	G3HZG9	Aspartate aminotransferase.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.453
I79_000092	Tgfb3	G3GRE7	G3HFS5	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.722
I79_000092	Tnf	G3GRE7	G3HZG9	Transforming growth factor beta; Belongs to the TGF-beta family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.427
I79_022257	Cd4	G3IEV3	G3GUN9	Actin.	T-cell surface glycoprotein CD4.	0.604