(18 nodes) (2020) Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays. network (Cricetulus griseus)

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second shell of interactors

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Your Input:
	Mdc1	Mediator of DNA damage checkpoint protein 1. (1490 aa)
	Cdk1	Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
	Bard1	BRCA1-associated RING domain protein 1. (670 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (281 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Plk1	Serine/threonine-protein kinase PLK. (602 aa)
	Ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	Casp8	Caspase-8; Belongs to the peptidase C14A family. (481 aa)
	Esr1	Estrogen receptor. (200 aa)
	I79_001487	Progesterone receptor. (741 aa)
	Hus1b	Checkpoint protein; Belongs to the HUS1 family. (277 aa)
	Fancd2	Fanconi anemia group D2 protein-like. (1068 aa)
	Sirt1	NAD-dependent deacetylase sirtuin-1. (554 aa)
	Ccna1	Cyclin-A1; Belongs to the cyclin family. (351 aa)
	Cdc25a	M-phase inducer phosphatase 1. (121 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
	Brca2	Breast cancer type 2 susceptibility protein-like. (3008 aa)
	CgPICR_018825	Cell division protein kinase 4. (121 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bard1	Brca1	G3HVP0	G3HM05	BRCA1-associated RING domain protein 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
Bard1	Brca2	G3HVP0	G3HM86	BRCA1-associated RING domain protein 1.	Breast cancer type 2 susceptibility protein-like.	0.977
Bard1	Ccna1	G3HVP0	G3HGB6	BRCA1-associated RING domain protein 1.	Cyclin-A1; Belongs to the cyclin family.	0.475
Bard1	Ccnd1	G3HVP0	A5A422	BRCA1-associated RING domain protein 1.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.429
Bard1	Cdk1	G3HVP0	G3HVL1	BRCA1-associated RING domain protein 1.	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.591
Bard1	CgPICR_018825	G3HVP0	G3HQ42	BRCA1-associated RING domain protein 1.	Cell division protein kinase 4.	0.542
Bard1	Esr1	G3HVP0	G3GU19	BRCA1-associated RING domain protein 1.	Estrogen receptor.	0.505
Bard1	Fancd2	G3HVP0	G3GX36	BRCA1-associated RING domain protein 1.	Fanconi anemia group D2 protein-like.	0.639
Bard1	Hus1	G3HVP0	G3HXX1	BRCA1-associated RING domain protein 1.	Checkpoint protein; Belongs to the HUS1 family.	0.655
Bard1	Hus1b	G3HVP0	G3GWX1	BRCA1-associated RING domain protein 1.	Checkpoint protein; Belongs to the HUS1 family.	0.655
Bard1	Mdc1	G3HVP0	G3HQP9	BRCA1-associated RING domain protein 1.	Mediator of DNA damage checkpoint protein 1.	0.838
Bard1	Plk1	G3HVP0	G3IN30	BRCA1-associated RING domain protein 1.	Serine/threonine-protein kinase PLK.	0.486
Brca1	Bard1	G3HM05	G3HVP0	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1-associated RING domain protein 1.	0.999
Brca1	Brca2	G3HM05	G3HM86	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Breast cancer type 2 susceptibility protein-like.	0.999
Brca1	Ccna1	G3HM05	G3HGB6	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cyclin-A1; Belongs to the cyclin family.	0.650
Brca1	Ccnd1	G3HM05	A5A422	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.660
Brca1	Cdc25a	G3HM05	G3HKQ6	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	M-phase inducer phosphatase 1.	0.442
Brca1	Cdk1	G3HM05	G3HVL1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.724
Brca1	CgPICR_018825	G3HM05	G3HQ42	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cell division protein kinase 4.	0.663
Brca1	Esr1	G3HM05	G3GU19	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Estrogen receptor.	0.961