STRINGSTRING
I79_010155 I79_010155 Stat3 Stat3 Bid Bid Ccnd1 Ccnd1 ABCB1 ABCB1 Casp7 Casp7 I79_021949 I79_021949 Rela Rela Timp1 Timp1 Tgfb1 Tgfb1 Gpt Gpt I79_018057 I79_018057 Gpt2 Gpt2 HSPA5 HSPA5 I79_020089 I79_020089 Casp8 Casp8 I79_001600 I79_001600 Cdk6 Cdk6 I79_003348 I79_003348 Map1a Map1a I79_004417 I79_004417 Mmp9 Mmp9 Bcl2 Bcl2 Abcc1 Abcc1 Ccna1 Ccna1 I79_009696 I79_009696
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_010155Sterol regulatory element-binding protein 1. (1050 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
ABCB1ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1276 aa)
Casp7Caspase-7. (303 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
RelaTranscription factor p65. (546 aa)
Timp1Metalloproteinase inhibitor 1-like protein. (203 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
GptAlanine aminotransferase 1. (481 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
Gpt2Alanine aminotransferase 2. (470 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
Casp8Caspase-8; Belongs to the peptidase C14A family. (481 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Cdk6Cell division protein kinase 6. (273 aa)
I79_003348Microtubule-associated protein 1A. (173 aa)
Map1aMicrotubule-associated protein 1A. (2585 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
Abcc1Multidrug resistance-associated protein 1. (146 aa)
Ccna1Cyclin-A1; Belongs to the cyclin family. (351 aa)
I79_009696Microtubule-associated protein 1A. (275 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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