(10 nodes) (2021) CADASIL from Bench to Bedside: Disease Models and Novel Therapeutic Approaches. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	I79_025798	Vitronectin. (230 aa)
	I79_022257	Actin. (98 aa)
	Pdgfrb	Beta-type platelet-derived growth factor receptor. (528 aa)
	Clu	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (447 aa)
	Heyl	Hairy/enhancer-of-split related with YRPW motif-like protein. (300 aa)
	Igfbp1	Insulin-like growth factor-binding protein 1. (272 aa)
	I79_009100	Latent-transforming growth factor beta-binding protein 1. (1194 aa)
	Rhoa	Transforming protein RhoA. (193 aa)
	Vtn	Vitronectin. (876 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Clu	I79_025798	G3HNJ3	G3IP93	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	Vitronectin.	0.571
Clu	Vtn	G3HNJ3	G3GTP7	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	Vitronectin.	0.567
Heyl	Jag1	G3HN78	G3GSA7	Hairy/enhancer-of-split related with YRPW motif-like protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.618
I79_009100	Pdgfrb	G3HEV3	G3HS35	Latent-transforming growth factor beta-binding protein 1.	Beta-type platelet-derived growth factor receptor.	0.517
I79_022257	Rhoa	G3IEV3	G3H8F9	Actin.	Transforming protein RhoA.	0.908
I79_025798	Clu	G3IP93	G3HNJ3	Vitronectin.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.571
Jag1	Heyl	G3GSA7	G3HN78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif-like protein.	0.618
Pdgfrb	I79_009100	G3HS35	G3HEV3	Beta-type platelet-derived growth factor receptor.	Latent-transforming growth factor beta-binding protein 1.	0.517
Rhoa	I79_022257	G3H8F9	G3IEV3	Transforming protein RhoA.	Actin.	0.908
Vtn	Clu	G3GTP7	G3HNJ3	Vitronectin.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.567