(11 nodes) (2021) Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Gp2	Pancreatic secretory granule membrane major glycoprotein GP2. (199 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
	Cd80	T-lymphocyte activation antigen CD80. (177 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Msln	Mesothelin. (335 aa)
	Il10	Interleukin-10. (178 aa)
	Cd86	T-lymphocyte activation antigen CD86. (269 aa)
	Ell	RNA polymerase II elongation factor ELL. (545 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd4	Cd80	G3GUN9	G3I1J7	T-cell surface glycoprotein CD4.	T-lymphocyte activation antigen CD80.	0.964
Cd4	Cd86	G3GUN9	G3HAJ6	T-cell surface glycoprotein CD4.	T-lymphocyte activation antigen CD86.	0.955
Cd4	Gp2	G3GUN9	G3IP11	T-cell surface glycoprotein CD4.	Pancreatic secretory granule membrane major glycoprotein GP2.	0.743
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Msln	G3GUN9	G3HBV0	T-cell surface glycoprotein CD4.	Mesothelin.	0.483
Cd4	Tlr3	G3GUN9	G3IHU2	T-cell surface glycoprotein CD4.	Toll-like receptor 3.	0.905
Cd4	Tlr4	G3GUN9	G3I192	T-cell surface glycoprotein CD4.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.914
Cd4	Tlr7	G3GUN9	G3I9Z2	T-cell surface glycoprotein CD4.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.912
Cd80	Cd4	G3I1J7	G3GUN9	T-lymphocyte activation antigen CD80.	T-cell surface glycoprotein CD4.	0.964
Cd80	Cd86	G3I1J7	G3HAJ6	T-lymphocyte activation antigen CD80.	T-lymphocyte activation antigen CD86.	0.997
Cd80	Ifng	G3I1J7	G3GY20	T-lymphocyte activation antigen CD80.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.860
Cd80	Il10	G3I1J7	G3HB01	T-lymphocyte activation antigen CD80.	Interleukin-10.	0.868
Cd80	Tlr3	G3I1J7	G3IHU2	T-lymphocyte activation antigen CD80.	Toll-like receptor 3.	0.648
Cd80	Tlr4	G3I1J7	G3I192	T-lymphocyte activation antigen CD80.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.759
Cd80	Tlr7	G3I1J7	G3I9Z2	T-lymphocyte activation antigen CD80.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.583
Cd86	Cd4	G3HAJ6	G3GUN9	T-lymphocyte activation antigen CD86.	T-cell surface glycoprotein CD4.	0.955
Cd86	Cd80	G3HAJ6	G3I1J7	T-lymphocyte activation antigen CD86.	T-lymphocyte activation antigen CD80.	0.997
Cd86	Ifng	G3HAJ6	G3GY20	T-lymphocyte activation antigen CD86.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.878
Cd86	Il10	G3HAJ6	G3HB01	T-lymphocyte activation antigen CD86.	Interleukin-10.	0.896