(31 nodes) (2021) Crk and CrkL as Therapeutic Targets for Cancer Treatment. network (Cricetulus griseus)

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Your Input:
	Hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
	I79_001024	Ephrin-B2; Belongs to the ephrin family. (373 aa)
	Pxn	Paxillin. (388 aa)
	I79_001232	Paxillin; Belongs to the phospholipase A2 family. (642 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Rhoa	Transforming protein RhoA. (193 aa)
	Mmp9	Matrix metalloproteinase-9. (710 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	Fos	Proto-oncogene protein c-fos. (381 aa)
	Crkl	Crk-like protein. (303 aa)
	Ccl21	C-C motif chemokine 21a. (148 aa)
	Ccl19	C-C motif chemokine. (117 aa)
	Zeb1	Zinc finger E-box-binding homeobox 1. (1078 aa)
	I79_013907	Ephrin-B2. (148 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	Ccr6	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	Fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
	Ccr7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	Aqp3	Aquaporin-3. (554 aa)
	Fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	I79_021151	Ephrin-B2. (178 aa)
	I79_022257	Actin. (98 aa)
	Fgfr2	Fibroblast growth factor receptor 2. (659 aa)
	I79_024975	Ephrin-B2. (148 aa)
	I79_025433	Ephrin-B2; Belongs to the ephrin family. (70 aa)
	I79_025496	Ephrin-B2. (147 aa)
	I79_025497	Ephrin-B2; Belongs to the ephrin family. (69 aa)
	I79_025518	Ephrin-B2. (123 aa)
	I79_025535	Ephrin-B2. (125 aa)
	I79_025726	Ephrin-B2. (121 aa)
	I79_026231	Ephrin-B2; Belongs to the ephrin family. (68 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccl19	Ccl21	G3HN20	G3HN19	C-C motif chemokine.	C-C motif chemokine 21a.	0.990
Ccl19	Ccr6	G3HN20	G3I4D2	C-C motif chemokine.	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.894
Ccl19	Ccr7	G3HN20	G3I5N8	C-C motif chemokine.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.999
Ccl21	Ccl19	G3HN19	G3HN20	C-C motif chemokine 21a.	C-C motif chemokine.	0.990
Ccl21	Ccr6	G3HN19	G3I4D2	C-C motif chemokine 21a.	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.868
Ccl21	Ccr7	G3HN19	G3I5N8	C-C motif chemokine 21a.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.999
Ccr6	Ccl19	G3I4D2	G3HN20	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.894
Ccr6	Ccl21	G3I4D2	G3HN19	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 21a.	0.868
Ccr6	Ccr7	G3I4D2	G3I5N8	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.640
Ccr7	Ccl19	G3I5N8	G3HN20	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.999
Ccr7	Ccl21	G3I5N8	G3HN19	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 21a.	0.999
Ccr7	Ccr6	G3I5N8	G3I4D2	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.640
Crkl	Fgfr2	G3HFZ9	G3IJY0	Crk-like protein.	Fibroblast growth factor receptor 2.	0.954
Crkl	Hgf	G3HFZ9	G3HPQ5	Crk-like protein.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.506
Crkl	I79_001232	G3HFZ9	G3GU78	Crk-like protein.	Paxillin; Belongs to the phospholipase A2 family.	0.720
Crkl	Pxn	G3HFZ9	G3GU77	Crk-like protein.	Paxillin.	0.970
Crkl	Rhoa	G3HFZ9	G3H8F9	Crk-like protein.	Transforming protein RhoA.	0.426
Crkl	Src	G3HFZ9	G3GXX7	Crk-like protein.	Tyrosine-protein kinase.	0.952
Fgf1	Fgf4	G3HEK8	G3I4D8	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.691
Fgf1	Fgf7	G3HEK8	G3IAS3	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.574