(34 nodes) (2021) Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells. network (Cricetulus griseus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	Emc7	UPF0480 protein C15orf24-like. (241 aa)
	Fkbp1a	Peptidylprolyl isomerase. (79 aa)
	Scfd1	Sec1 family domain-containing protein 1; Belongs to the STXBP/unc-18/SEC1 family. (634 aa)
	Golph3l	Golgi phosphoprotein 3-like. (285 aa)
	Ddhd2	Phospholipase DDHD2. (697 aa)
	Copg2	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (808 aa)
	Pdcd6	Programmed cell death protein 6. (83 aa)
	I79_002536	Pro-opiomelanocortin. (159 aa)
	Prkcd	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (437 aa)
	Lpp	Lipoma-preferred partner. (355 aa)
	Dnajc3	DnaJ-like subfamily C member 3. (502 aa)
	Tmf1	TATA element modulatory factor. (1094 aa)
	I79_025220	Serum albumin. (186 aa)
	Zfpl1	Zinc finger protein-like 1. (310 aa)
	Srp72	Signal recognition particle 72 kDa protein. (476 aa)
	Alb	Serum albumin. (430 aa)
	Trappc9	Trafficking protein particle complex subunit 9. (604 aa)
	Surf4	Surfeit locus protein 4. (260 aa)
	Mcfd2	Multiple coagulation factor deficiency protein 2-like. (145 aa)
	B4galt1	Beta-1,4-galactosyltransferase 1. (258 aa)
	Rab32	Ras-related protein Rab-32. (223 aa)
	Pitpnm1	Membrane-associated phosphatidylinositol transfer protein 1. (1244 aa)
	Serpina1	Alpha-1-antitrypsin; Belongs to the serpin family. (412 aa)
	Psmg1	Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2. (289 aa)
	St6gal1	Beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (402 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	Fkbp14	Peptidylprolyl isomerase. (211 aa)
	Os9	Protein OS-9-like isoform 1. (669 aa)
	Ufc1	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa)
	Stx17	Syntaxin-17; Belongs to the syntaxin family. (263 aa)
	I79_013097	Dymeclin. (443 aa)
	Clu	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (447 aa)
	Tmed4	Transmembrane emp24 domain-containing protein 4. (227 aa)
	Copg1	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (874 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alb	I79_025220	G3IAL6	G3IMS5	Serum albumin.	Serum albumin.	0.960
Alb	Ins	G3IAL6	G3HXZ8	Serum albumin.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.879
Alb	Serpina1	G3IAL6	G3I296	Serum albumin.	Alpha-1-antitrypsin; Belongs to the serpin family.	0.697
B4galt1	St6gal1	G3I8W2	G3HYF9	Beta-1,4-galactosyltransferase 1.	Beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.	0.996
B4galt1	Tmf1	G3I8W2	G3GS63	Beta-1,4-galactosyltransferase 1.	TATA element modulatory factor.	0.426
B4galt1	Zfpl1	G3I8W2	G3IJ21	Beta-1,4-galactosyltransferase 1.	Zinc finger protein-like 1.	0.414
Clu	Serpina1	G3HNJ3	G3I296	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	Alpha-1-antitrypsin; Belongs to the serpin family.	0.421
Copg1	Copg2	G3HID3	G3GZ72	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.511
Copg1	Ddhd2	G3HID3	G3H1I9	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Phospholipase DDHD2.	0.446
Copg1	Emc7	G3HID3	G3HIH0	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	UPF0480 protein C15orf24-like.	0.402
Copg1	Fkbp1a	G3HID3	G3H6Y5	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Peptidylprolyl isomerase.	0.419
Copg1	Golph3l	G3HID3	G3H2X3	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Golgi phosphoprotein 3-like.	0.486
Copg1	I79_013097	G3HID3	G3HQJ3	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Dymeclin.	0.435
Copg1	Pitpnm1	G3HID3	G3I3Z0	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Membrane-associated phosphatidylinositol transfer protein 1.	0.701
Copg1	Scfd1	G3HID3	G3H4J6	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Sec1 family domain-containing protein 1; Belongs to the STXBP/unc-18/SEC1 family.	0.668
Copg1	Srp72	G3HID3	G3IFL3	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Signal recognition particle 72 kDa protein.	0.512
Copg1	Surf4	G3HID3	G3I9S0	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Surfeit locus protein 4.	0.643
Copg1	Tmed4	G3HID3	G3HMB2	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Transmembrane emp24 domain-containing protein 4.	0.682
Copg1	Tmf1	G3HID3	G3GS63	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	TATA element modulatory factor.	0.720
Copg1	Trappc9	G3HID3	G3IAE8	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Trafficking protein particle complex subunit 9.	0.539