(10 nodes) (2021) Cardiac effects and clinical applications of MG53. network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_013066	Dysferlin. (1296 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	Tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	Sgcd	Delta-sarcoglycan. (140 aa)
	CgPICR_017317	Insulin receptor substrate 1. (493 aa)
	Irs1	Insulin receptor substrate 1. (1233 aa)
	Irs2	Insulin receptor substrate 2. (465 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cav3	I79_013066	G3H113	G3HQG6	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Dysferlin.	0.963
Cav3	Ins	G3H113	G3HXZ8	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.414
Cav3	Sgcd	G3H113	G3I3C1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Delta-sarcoglycan.	0.730
CgPICR_017317	Ins	G3I658	G3HXZ8	Insulin receptor substrate 1.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.996
CgPICR_017317	Irs1	G3I658	G3IDC4	Insulin receptor substrate 1.	Insulin receptor substrate 1.	0.901
CgPICR_017317	Irs2	G3I658	G3IKD0	Insulin receptor substrate 1.	Insulin receptor substrate 2.	0.996
CgPICR_017317	Stat3	G3I658	G3HLW9	Insulin receptor substrate 1.	Signal transducer and activator of transcription.	0.475
I79_000092	Tgfb3	G3GRE7	G3HFS5	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.722
I79_013066	Cav3	G3HQG6	G3H113	Dysferlin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
I79_013066	Sgcd	G3HQG6	G3I3C1	Dysferlin.	Delta-sarcoglycan.	0.693
Ins	Cav3	G3HXZ8	G3H113	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.414
Ins	CgPICR_017317	G3HXZ8	G3I658	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Insulin receptor substrate 1.	0.996
Ins	Irs1	G3HXZ8	G3IDC4	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Insulin receptor substrate 1.	0.996
Ins	Irs2	G3HXZ8	G3IKD0	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Insulin receptor substrate 2.	0.986
Ins	Stat3	G3HXZ8	G3HLW9	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	Signal transducer and activator of transcription.	0.694
Irs1	CgPICR_017317	G3IDC4	G3I658	Insulin receptor substrate 1.	Insulin receptor substrate 1.	0.901
Irs1	Ins	G3IDC4	G3HXZ8	Insulin receptor substrate 1.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.996
Irs1	Irs2	G3IDC4	G3IKD0	Insulin receptor substrate 1.	Insulin receptor substrate 2.	0.987
Irs1	Stat3	G3IDC4	G3HLW9	Insulin receptor substrate 1.	Signal transducer and activator of transcription.	0.507
Irs2	CgPICR_017317	G3IKD0	G3I658	Insulin receptor substrate 2.	Insulin receptor substrate 1.	0.996