STRINGSTRING
Stat2 Stat2 IL2 IL2 Foxa2 Foxa2 Jak1 Jak1 I79_016164 I79_016164 Tlr4 Tlr4 NOTCH1 NOTCH1 Foxa1 Foxa1 Stat1 Stat1 Tlr8 Tlr8 Tlr7 Tlr7 Rela Rela Jak2 Jak2 I79_023218 I79_023218 Irf2 Irf2 Tlr3 Tlr3 I79_025440 I79_025440 Myd88 Myd88 Stat3 Stat3 Il15 Il15 Ace Ace Ifnar1 Ifnar1 Irf4 Irf4 Ifng Ifng Traf6 Traf6 Tab2 Tab2 Jak3 Jak3 Nr2f6 Nr2f6 Tyk2 Tyk2 Nodal Nodal Irf9 Irf9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Stat2Signal transducer and activator of transcription. (806 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Foxa2Hepatocyte nuclear factor 3-beta. (430 aa)
Jak1Tyrosine-protein kinase. (1140 aa)
I79_016164P-selectin. (1330 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
NOTCH1Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2527 aa)
Foxa1Hepatocyte nuclear factor 3-alpha. (434 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
Tlr8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1027 aa)
Tlr7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
RelaTranscription factor p65. (546 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_023218Interferon regulatory factor 3. (377 aa)
Irf2Interferon regulatory factor. (349 aa)
Tlr3Toll-like receptor 3. (164 aa)
I79_025440Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
AceAngiotensin-converting enzyme. (791 aa)
Ifnar1Interferon-alpha/beta receptor alpha chain. (483 aa)
Irf4Interferon regulatory factor 4. (418 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
Tab2Mitogen-activated protein kinase kinase kinase 7-interacting protein 2. (693 aa)
Jak3Tyrosine-protein kinase JAK3. (222 aa)
Nr2f6Nuclear receptor subfamily 2 group F member 6. (91 aa)
Tyk2Tyrosine-protein kinase. (1182 aa)
NodalNodal. (309 aa)
Irf9Interferon regulatory factor 9. (398 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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