STRINGSTRING
I79_011712 I79_011712 Stat2 Stat2 Stat6 Stat6 Pik3c3 Pik3c3 I79_017574 I79_017574 I79_018057 I79_018057 I79_019128 I79_019128 Stat1 Stat1 I79_020424 I79_020424 I79_020755 I79_020755 I79_020843 I79_020843 Reck Reck I79_021198 I79_021198 I79_021949 I79_021949 Mtor Mtor I79_023874 I79_023874 Ccnt1 Ccnt1 I79_025861 I79_025861 ABCB1 ABCB1 Zeb1 Zeb1 Ca9 Ca9 Stat3 Stat3 Hgf Hgf Casp2 Casp2 Il15 Il15 Slc2a1 Slc2a1 Bcl2 Bcl2 Pklr Pklr I79_007693 I79_007693 I79_006999 I79_006999 Mmp9 Mmp9 Rhoa Rhoa Pcna Pcna Pkm Pkm I79_004417 I79_004417 Cxcr4 Cxcr4 Ccnt2 Ccnt2 Fasn Fasn I79_001600 I79_001600 Nos1 Nos1 Lyrm9 Lyrm9 Casp8 Casp8 Ccnd1 Ccnd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_011712Signal transducer and activator of transcription. (793 aa)
Stat2Signal transducer and activator of transcription. (806 aa)
Stat6Signal transducer and activator of transcription. (844 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (822 aa)
I79_017574Caspase-12; Belongs to the peptidase C14A family. (729 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
I79_019128Multidrug resistance protein 1. (438 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
I79_020424Pyruvate kinase; Belongs to the pyruvate kinase family. (258 aa)
I79_020755Pyruvate kinase; Belongs to the pyruvate kinase family. (461 aa)
I79_020843Reversion-inducing cysteine-rich protein with Kazal motifs. (107 aa)
ReckReversion-inducing cysteine-rich protein with Kazal motifs. (714 aa)
I79_021198Acetyl-CoA carboxylase 1. (231 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_023874Pyruvate kinase; Belongs to the pyruvate kinase family. (233 aa)
Ccnt1Cyclin-T1; Belongs to the cyclin family. (729 aa)
I79_025861Multidrug resistance protein 1. (151 aa)
ABCB1ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1276 aa)
Zeb1Zinc finger E-box-binding homeobox 1. (1078 aa)
Ca9Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (182 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
Casp2Caspase-2; Belongs to the peptidase C14A family. (421 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
Slc2a1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (486 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
PklrPyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
I79_007693Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
I79_006999Acetyl-CoA carboxylase 1. (1579 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
RhoaTransforming protein RhoA. (193 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PkmPyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Cxcr4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (290 aa)
Ccnt2Cyclin-T2; Belongs to the cyclin family. (724 aa)
FasnFatty acid synthase. (2503 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
Lyrm9Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
Casp8Caspase-8; Belongs to the peptidase C14A family. (481 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.