(15 nodes) (2021) Recent Advances of COVID-19 Modeling Based on Regenerative Medicine. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Csf3	Granulocyte colony-stimulating factor. (208 aa)
	F3	Tissue factor. (293 aa)
	Ccn1	Protein CYR61. (491 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Stat2	Signal transducer and activator of transcription. (806 aa)
	Ace	Angiotensin-converting enzyme. (791 aa)
	Il10	Interleukin-10. (178 aa)
	I79_007067	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1107 aa)
	Csf2	Granulocyte-macrophage colony-stimulating factor. (95 aa)
	Agt	Angiotensinogen; Belongs to the serpin family. (477 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Cldn1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	Ifnar1	Interferon-alpha/beta receptor alpha chain. (483 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ace	Agt	G3HGE5	G3GX14	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.917
Ace	Cd4	G3HGE5	G3GUN9	Angiotensin-converting enzyme.	T-cell surface glycoprotein CD4.	0.577
Ace	IL2	G3HGE5	G3HTL8	Angiotensin-converting enzyme.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.579
Ace	Il10	G3HGE5	G3HB01	Angiotensin-converting enzyme.	Interleukin-10.	0.440
Agt	Ace	G3GX14	G3HGE5	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme.	0.917
Agt	Cd4	G3GX14	G3GUN9	Angiotensinogen; Belongs to the serpin family.	T-cell surface glycoprotein CD4.	0.509
Agt	Tnf	G3GX14	G3HZG9	Angiotensinogen; Belongs to the serpin family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.528
Cd4	Ace	G3GUN9	G3HGE5	T-cell surface glycoprotein CD4.	Angiotensin-converting enzyme.	0.577
Cd4	Agt	G3GUN9	G3GX14	T-cell surface glycoprotein CD4.	Angiotensinogen; Belongs to the serpin family.	0.509
Cd4	Cldn1	G3GUN9	G3GT81	T-cell surface glycoprotein CD4.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.671
Cd4	Csf2	G3GUN9	G3H567	T-cell surface glycoprotein CD4.	Granulocyte-macrophage colony-stimulating factor.	0.856
Cd4	Csf3	G3GUN9	G3INY3	T-cell surface glycoprotein CD4.	Granulocyte colony-stimulating factor.	0.748
Cd4	IL2	G3GUN9	G3HTL8	T-cell surface glycoprotein CD4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.974
Cd4	Ifnar1	G3GUN9	G3GT51	T-cell surface glycoprotein CD4.	Interferon-alpha/beta receptor alpha chain.	0.771
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Stat1	G3GUN9	G3I9F9	T-cell surface glycoprotein CD4.	Signal transducer and activator of transcription.	0.893
Cd4	Stat2	G3GUN9	G3HRN9	T-cell surface glycoprotein CD4.	Signal transducer and activator of transcription.	0.804
Cd4	Tnf	G3GUN9	G3HZG9	T-cell surface glycoprotein CD4.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.884
Cldn1	Cd4	G3GT81	G3GUN9	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	T-cell surface glycoprotein CD4.	0.671
Cldn1	Il10	G3GT81	G3HB01	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin-10.	0.515