(18 nodes) (2021) Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest. network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	Cd34	Hematopoietic progenitor cell antigen CD34. (383 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	Cxcl12	Stromal cell-derived factor 1. (89 aa)
	Ccr7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	Ccr6	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	Dlk1	Protein delta-like 1. (361 aa)
	Ccl19	C-C motif chemokine. (117 aa)
	Ccl21	C-C motif chemokine 21a. (148 aa)
	Ccl17	C-C motif chemokine. (93 aa)
	Ido1	Indoleamine 2,3-dioxygenase 1. (567 aa)
	Pxdn	Peroxidasin-like. (1475 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Ctla4	Cytotoxic T-lymphocyte protein 4. (171 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Nos1	Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
	Lyrm9	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccl17	Ccl19	G3HIL3	G3HN20	C-C motif chemokine.	C-C motif chemokine.	0.587
Ccl17	Ccl21	G3HIL3	G3HN19	C-C motif chemokine.	C-C motif chemokine 21a.	0.627
Ccl17	Ccl5	G3HIL3	G3I8B1	C-C motif chemokine.	C-C motif chemokine.	0.996
Ccl17	Ccr6	G3HIL3	G3I4D2	C-C motif chemokine.	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.879
Ccl17	Ccr7	G3HIL3	G3I5N8	C-C motif chemokine.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.859
Ccl17	Cd4	G3HIL3	G3GUN9	C-C motif chemokine.	T-cell surface glycoprotein CD4.	0.801
Ccl17	Cxcl12	G3HIL3	G3I6P7	C-C motif chemokine.	Stromal cell-derived factor 1.	0.576
Ccl17	Ifng	G3HIL3	G3GY20	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.595
Ccl19	Ccl17	G3HN20	G3HIL3	C-C motif chemokine.	C-C motif chemokine.	0.587
Ccl19	Ccl21	G3HN20	G3HN19	C-C motif chemokine.	C-C motif chemokine 21a.	0.990
Ccl19	Ccl5	G3HN20	G3I8B1	C-C motif chemokine.	C-C motif chemokine.	0.639
Ccl19	Ccr6	G3HN20	G3I4D2	C-C motif chemokine.	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.894
Ccl19	Ccr7	G3HN20	G3I5N8	C-C motif chemokine.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.999
Ccl19	Cd4	G3HN20	G3GUN9	C-C motif chemokine.	T-cell surface glycoprotein CD4.	0.813
Ccl19	Cxcl12	G3HN20	G3I6P7	C-C motif chemokine.	Stromal cell-derived factor 1.	0.917
Ccl19	Ifng	G3HN20	G3GY20	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.564
Ccl21	Ccl17	G3HN19	G3HIL3	C-C motif chemokine 21a.	C-C motif chemokine.	0.627
Ccl21	Ccl19	G3HN19	G3HN20	C-C motif chemokine 21a.	C-C motif chemokine.	0.990
Ccl21	Ccl5	G3HN19	G3I8B1	C-C motif chemokine 21a.	C-C motif chemokine.	0.648
Ccl21	Ccr6	G3HN19	G3I4D2	C-C motif chemokine 21a.	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.868