STRINGSTRING
Esr1 Esr1 Cdh15 Cdh15 Ccnd1 Ccnd1 Dusp4 Dusp4 Hoxb13 Hoxb13 Pcna Pcna Kras Kras I79_004417 I79_004417 Tp53 Tp53 Mdm2 Mdm2 Ifng Ifng Dusp22 Dusp22 I79_001600 I79_001600 Il33 Il33 Ep300 Ep300 Ccl5 Ccl5 I79_020089 I79_020089 Klf4 Klf4 Ccn1 Ccn1 Tet2 Tet2 I79_021949 I79_021949 Mtor Mtor Fancc Fancc Tert Tert Smyd3 Smyd3 Ets1 Ets1 Wnt5b Wnt5b Mmp9 Mmp9 Hdac1 Hdac1 E2f1 E2f1 Cacna1a Cacna1a Bcl2 Bcl2 Dusp15 Dusp15 Snai1 Snai1 Sfrp1 Sfrp1 Chst10 Chst10 Hdac2 Hdac2 Il15 Il15 Hdac5 Hdac5 Stat3 Stat3 Col8a1 Col8a1 Runx3 Runx3 Hdac6 Hdac6 Rgs4 Rgs4 Ahr Ahr Sp1 Sp1 PPARG PPARG Cdk1 Cdk1 Limd1 Limd1 Hdac4 Hdac4 Ctcf Ctcf Nqo1 Nqo1 Col4a2 Col4a2 Nnmt Nnmt Kctd5 Kctd5 I79_018057 I79_018057 Gstp1 Gstp1 Tgfbr1 Tgfbr1 Tet1 Tet1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Esr1Estrogen receptor. (200 aa)
Cdh15Cadherin-15; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Dusp4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
Hoxb13Homeobox protein Hox-B13. (284 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
KrasGTPase KRas. (155 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Tp53Cellular tumor antigen p53. (148 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (476 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
Dusp22Dual specificity protein phosphatase 22. (197 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Il33Interleukin-33. (217 aa)
Ep300Histone acetyltransferase p300. (2415 aa)
Ccl5C-C motif chemokine. (91 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
Klf4Krueppel-like factor 4. (474 aa)
Ccn1Protein CYR61. (491 aa)
Tet2Putative methylcytosine dioxygenase TET2. (273 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
FanccFanconi anemia group C protein-like. (254 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
Smyd3SET and MYND domain-containing protein 3. (239 aa)
Ets1Protein C-ets-1. (257 aa)
Wnt5bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
Hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
E2f1Transcription factor E2F1. (367 aa)
Cacna1aVoltage-dependent P/Q-type calcium channel subunit alpha-1A. (78 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
Dusp15Dual specificity protein phosphatase 15; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (307 aa)
Snai1Zinc finger protein SNAI1-like protein. (264 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
Chst10Carbohydrate sulfotransferase. (288 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
Hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Col8a1Collagen alpha-1(VIII) chain. (745 aa)
Runx3Runt-related transcription factor 3. (299 aa)
Hdac6Histone deacetylase 6. (666 aa)
Rgs4Regulator of G-protein signaling 4. (206 aa)
AhrAryl hydrocarbon receptor. (247 aa)
Sp1Transcription factor Sp1. (778 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Cdk1Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
Limd1LIM domain-containing protein 1. (667 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
CtcfTranscriptional repressor CTCF. (734 aa)
Nqo1NAD(P)H dehydrogenase [quinone] 1. (274 aa)
Col4a2Collagen alpha-2(IV) chain. (350 aa)
NnmtNicotinamide N-methyltransferase. (265 aa)
Kctd53-phosphoinositide-dependent protein kinase 1; Belongs to the peptidase S1 family. (799 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
Gstp1Glutathione S-transferase P. (221 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)
Tet1Methylcytosine dioxygenase TET1. (1466 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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