STRINGSTRING
Irs2 Irs2 Ppara Ppara Irs1 Irs1 Tgfb1 Tgfb1 Ucp3 Ucp3 Slc2a2 Slc2a2 CgPICR_017317 CgPICR_017317 IL1B IL1B Fgf21 Fgf21 Hif1a Hif1a Adipoq Adipoq I79_015980 I79_015980 Ins Ins Insr Insr PPARG PPARG Pdk4 Pdk4 Mc2r Mc2r Mc4r Mc4r Pklr Pklr Pck1 Pck1 Igf1 Igf1 Nfe2l2 Nfe2l2 B2m B2m Apob Apob Lep Lep Slc2a4 Slc2a4 Cd68 Cd68 Fasn Fasn Klb Klb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Irs2Insulin receptor substrate 2. (465 aa)
PparaPeroxisome proliferator-activated receptor alpha. (393 aa)
Irs1Insulin receptor substrate 1. (1233 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Ucp3Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (650 aa)
Slc2a2Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (351 aa)
CgPICR_017317Insulin receptor substrate 1. (493 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
Fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
Hif1aHypoxia-inducible factor 1 alpha. (820 aa)
AdipoqAdiponectin. (248 aa)
I79_015980Leptin receptor. (533 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
InsrInsulin receptor. (114 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Pdk4Protein-serine/threonine kinase. (178 aa)
Mc2rAdrenocorticotropic hormone receptor. (297 aa)
Mc4rMelanocortin receptor 4. (332 aa)
PklrPyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
Pck1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
Igf1Insulin-like growth factor I. (75 aa)
Nfe2l2Nuclear factor erythroid 2-related factor 2. (588 aa)
B2mBeta-2-microglobulin. (54 aa)
ApobApolipoprotein B-100. (3537 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Slc2a4Solute carrier family 2, facilitated glucose transporter member 4. (90 aa)
Cd68Macrosialin. (294 aa)
FasnFatty acid synthase. (2503 aa)
KlbBeta-klotho; Belongs to the glycosyl hydrolase 1 family. (730 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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