| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Foxo1 | Gcg | G3HZV8 | G3HZV5 | Forkhead box protein O1. | Seprase; Belongs to the peptidase S9B family. | 0.434 |
| Foxo1 | I79_022390 | G3HZV8 | G3IF74 | Forkhead box protein O1. | Peroxisome proliferator-activated receptor alpha. | 0.405 |
| Foxo1 | Ins | G3HZV8 | G3HXZ8 | Forkhead box protein O1. | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | 0.772 |
| Foxo1 | Lep | G3HZV8 | G3GZ86 | Forkhead box protein O1. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.544 |
| Foxo1 | PPARG | G3HZV8 | G3HVG0 | Forkhead box protein O1. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.691 |
| Foxo1 | Ppargc1a | G3HZV8 | G3HWZ1 | Forkhead box protein O1. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha. | 0.990 |
| Gcg | Foxo1 | G3HZV5 | G3HZV8 | Seprase; Belongs to the peptidase S9B family. | Forkhead box protein O1. | 0.434 |
| Gcg | Ins | G3HZV5 | G3HXZ8 | Seprase; Belongs to the peptidase S9B family. | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | 0.944 |
| Gcg | Lep | G3HZV5 | G3GZ86 | Seprase; Belongs to the peptidase S9B family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.880 |
| Gcg | PPARG | G3HZV5 | G3HVG0 | Seprase; Belongs to the peptidase S9B family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.463 |
| I79_022257 | Ins | G3IEV3 | G3HXZ8 | Actin. | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | 0.609 |
| I79_022390 | Foxo1 | G3IF74 | G3HZV8 | Peroxisome proliferator-activated receptor alpha. | Forkhead box protein O1. | 0.405 |
| I79_022390 | Ins | G3IF74 | G3HXZ8 | Peroxisome proliferator-activated receptor alpha. | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | 0.663 |
| I79_022390 | Lep | G3IF74 | G3GZ86 | Peroxisome proliferator-activated receptor alpha. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.588 |
| I79_022390 | PPARG | G3IF74 | G3HVG0 | Peroxisome proliferator-activated receptor alpha. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.787 |
| I79_022390 | Ppara | G3IF74 | G3IF76 | Peroxisome proliferator-activated receptor alpha. | Peroxisome proliferator-activated receptor alpha. | 0.565 |
| I79_022390 | Ppargc1a | G3IF74 | G3HWZ1 | Peroxisome proliferator-activated receptor alpha. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha. | 0.928 |
| Ins | Foxo1 | G3HXZ8 | G3HZV8 | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | Forkhead box protein O1. | 0.772 |
| Ins | Gcg | G3HXZ8 | G3HZV5 | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | Seprase; Belongs to the peptidase S9B family. | 0.944 |
| Ins | I79_022257 | G3HXZ8 | G3IEV3 | Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. | Actin. | 0.609 |