STRINGSTRING
Fgf3 Fgf3 Got2 Got2 Tlr4 Tlr4 Fgf21 Fgf21 I79_016618 I79_016618 Adipoq Adipoq Ins Ins Npm3 Npm3 PPARG PPARG Dgat2 Dgat2 I79_013606 I79_013606 Fgf16 Fgf16 Fgf14 Fgf14 Sirt2 Sirt2 Il15 Il15 I79_010155 I79_010155 Tgfb3 Tgfb3 Fgf22 Fgf22 Fgf1 Fgf1 Cyp7a1 Cyp7a1 Fgf13 Fgf13 I79_006966 I79_006966 Nr3c2 Nr3c2 I79_006679 I79_006679 Lgals3 Lgals3 Thrb Thrb Got1 Got1 Fgf20 Fgf20 Lep Lep Fasn Fasn Gcgr Gcgr Loxl2 Loxl2 Fgf17 Fgf17 I79_001364 I79_001364 Fgf23 Fgf23 I79_001236 I79_001236 SIRT4 SIRT4 Fgf12 Fgf12 I79_000092 I79_000092 Klb Klb CgPICR_009695 CgPICR_009695 I79_020968 I79_020968 Fgf7 Fgf7 Apoc3 Apoc3 I79_019149 I79_019149 Fgf4 Fgf4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
Got2Aspartate aminotransferase. (430 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
I79_016618Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (470 aa)
AdipoqAdiponectin. (248 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
Npm3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Dgat2Diacylglycerol O-acyltransferase 2. (388 aa)
I79_013606Multidrug resistance protein 3. (1022 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
Fgf14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
Sirt2NAD-dependent deacetylase sirtuin-2. (83 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
I79_010155Sterol regulatory element-binding protein 1. (1050 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
Fgf22Fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (70 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Cyp7a1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (360 aa)
Fgf13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (117 aa)
I79_006966Mineralocorticoid receptor. (301 aa)
Nr3c2Mineralocorticoid receptor. (586 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
Lgals3Galectin. (281 aa)
ThrbThyroid hormone receptor beta. (377 aa)
Got1Aspartate aminotransferase. (413 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
FasnFatty acid synthase. (2503 aa)
GcgrGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (486 aa)
Loxl2Lysyl oxidase-like 2. (300 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (350 aa)
I79_001364Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
Fgf23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
I79_001236Bile salt export pump. (1096 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (255 aa)
Fgf12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (165 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
KlbBeta-klotho; Belongs to the glycosyl hydrolase 1 family. (730 aa)
CgPICR_009695Cytochrome P450 2E1; Belongs to the cytochrome P450 family. (493 aa)
I79_020968Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (104 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Apoc3Apolipoprotein C-III. (76 aa)
I79_019149Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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