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Adamts5 Adamts5 I79_017574 I79_017574 Tlr4 Tlr4 I79_016240 I79_016240 Sod2 Sod2 I79_001092 I79_001092 I79_015170 I79_015170 Becn1 Becn1 Gfap Gfap I79_010620 I79_010620 Egr1 Egr1 Fgf1 Fgf1 Bcl2 Bcl2 Il10 Il10 Keap1 Keap1 Ckb Ckb Txnip Txnip Glb1 Glb1 I79_004417 I79_004417 Ckmt1b Ckmt1b Ctsb Ctsb Ifng Ifng I79_001600 I79_001600 I79_022390 I79_022390 Adrb2 Adrb2 I79_021949 I79_021949 Gusb Gusb Bace1 Bace1 Nox4 Nox4 I79_020089 I79_020089 Cd4 Cd4 I79_001093 I79_001093 Ctsd Ctsd I79_018057 I79_018057 Ache Ache Ppara Ppara
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Adamts5A disintegrin and metalloproteinase with thrombospondin motifs 5. (936 aa)
I79_017574Caspase-12; Belongs to the peptidase C14A family. (729 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
I79_016240Beclin-1. (119 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
I79_001092Beta-galactosidase. (680 aa)
I79_015170Beta-galactosidase. (615 aa)
Becn1Beclin-1. (448 aa)
GfapGlial fibrillary acidic protein; Belongs to the intermediate filament family. (427 aa)
I79_010620Alpha-synuclein; Belongs to the synuclein family. (166 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
Il10Interleukin-10. (178 aa)
Keap1Kelch-like ECH-associated protein 1. (624 aa)
CkbCreatine kinase B-type; Belongs to the ATP:guanido phosphotransferase family. (203 aa)
TxnipThioredoxin-interacting protein. (229 aa)
Glb1Beta-galactosidase. (650 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Ckmt1bCreatine kinase U-type, mitochondrial; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
CtsbCathepsin B; Belongs to the peptidase C1 family. (339 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
I79_022390Peroxisome proliferator-activated receptor alpha. (110 aa)
Adrb2Beta-2 adrenergic receptor. (337 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
GusbBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (648 aa)
Bace1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
Nox4NADPH oxidase 4. (130 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
I79_001093Beta-galactosidase. (659 aa)
CtsdCathepsin D; Belongs to the peptidase A1 family. (408 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
AcheCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (575 aa)
PparaPeroxisome proliferator-activated receptor alpha. (393 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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